Vaccines are the key technology to combat existing and emerging infectious diseases.
However, increasing the potency, quality and durability of the vaccine response remains a …

B cells and the antibodies they produce have a deeply penetrating influence on human
physiology. Here, we review current understanding of how B cell responses are initiated; the …

Since the discovery of messenger RNA (mRNA), there have been tremendous efforts to
wield them in the development of therapeutics and vaccines. During the COVID-19 …

Germinal centers (GCs) are microanatomical sites of B cell clonal expansion and antibody
affinity maturation. Therein, B cells undergo the Darwinian process of somatic diversification …

Protein nanoparticle scaffolds are increasingly used in next-generation vaccine designs,
and several have established records of clinical safety and efficacy. Yet the rules for how …

Antibody immunodominance refers to the preferential and asymmetric elicitation of
antibodies against specific epitopes on a complex protein antigen. Traditional vaccination …

ABSTRACT HIV viremia can be controlled by chronic antiretroviral therapy. As a potentially
single-shot alternative, B cells engineered by CRISPR/Cas9 to express anti-HIV broadly …

The majority of all vaccines work by inducing protective antibody responses. The
mechanisms by which the B cells responsible for producing protective antibodies are elicited …

Antibodies are critical for providing protection against influenza virus infections. However,
protective humoral immunity against influenza viruses is limited by the antigenic drift and …

Ticks are second to mosquitoes as vectors of disease. Ticks affect livestock industries in
Asia, Africa and Australia at~ 1.13billionUSDperannum.Forinstance,80%oftheglobalcattlepopulationisatriskofinfestati …