Role of metals in Alzheimer's disease

N Das, J Raymick, S Sarkar - Metabolic brain disease, 2021 - Springer
Metal homeostasis in the central nervous system (CNS) is a crucial component of healthy
brain function, because metals serve as enzymatic cofactors and are key components of …

Necroptosis in neurodegenerative diseases: a potential therapeutic target

S Zhang, M Tang, H Luo, C Shi, Y Xu - Cell death & disease, 2017 - nature.com
Neurodegenerative diseases are a group of chronic progressive disorders characterized by
neuronal loss. Necroptosis, a recently discovered form of programmed cell death, is a cell …

Neuroprotective effect of cardamom oil against aluminum induced neurotoxicity in rats

ST Auti, YA Kulkarni - Frontiers in neurology, 2019 - frontiersin.org
Acetylcholinesterase (AChE) is an enzyme involved in the progression of Alzheimer's
disease (AD). Cardamom oil (CO) has been reported to have acetylcholinesterase inhibitory …

Evaluating potential of curcumin loaded solid lipid nanoparticles in aluminium induced behavioural, biochemical and histopathological alterations in mice brain

V Kakkar, IP Kaur - Food and chemical toxicology, 2011 - Elsevier
Aluminium, a well established neurotoxicant, is reported to be involved in the aetiology of
Alzheimer's disease (AD) due to its easy admittance and accumulation in central nervous …

A mechanistic survey of Alzheimer's disease

Y Tang, D Zhang, X Gong, J Zheng - Biophysical chemistry, 2022 - Elsevier
Alzheimer's disease (AD) is the most common, age-dependent neurodegenerative disorder.
While AD has been intensively studied from different aspects, there is no effective cure for …

Protective effect of curcumin (Curcuma longa), against aluminium toxicity: Possible behavioral and biochemical alterations in rats

A Kumar, S Dogra, A Prakash - Behavioural brain research, 2009 - Elsevier
Aluminium is a potent neurotoxin and has been associated with Alzheimer's disease (AD)
causality for decades. Prolonged aluminium exposure induces oxidative stress and …

Quercetin attenuates neuronal death against aluminum-induced neurodegeneration in the rat hippocampus

DR Sharma, WY Wani, A Sunkaria, RJ Kandimalla… - Neuroscience, 2016 - Elsevier
Aluminum is a light weight and toxic metal present ubiquitously on earth, which has gained
considerable attention due to its neurotoxic effects. It also has been linked ecologically and …

Metal ions influx is a double edged sword for the pathogenesis of Alzheimer's disease

P Wang, ZY Wang - Ageing Research Reviews, 2017 - Elsevier
Alzheimer's disease (AD) is a common form of dementia in aged people, which is defined by
two pathological characteristics: β-amyloid protein (Aβ) deposition and tau …

Protective effect of selenium against aluminum chloride-induced Alzheimer's disease: behavioral and biochemical alterations in rats

BVS Lakshmi, M Sudhakar, KS Prakash - Biological trace element …, 2015 - Springer
In present study, selenium was selected for evaluating effect of selenium on aluminum
chloride (AlCl 3)-induced Alzheimer's disease in rats. Thirty Wistar rats were divided into five …

Hesperidin and silibinin ameliorate aluminum-induced neurotoxicity: modulation of antioxidants and inflammatory cytokines level in mice hippocampus

A Jangra, P Kasbe, SN Pandey, S Dwivedi… - Biological trace element …, 2015 - Springer
Mounting evidence suggests that long-term aluminum exposure results in severe toxic
effects, including neurobehavioral and neurochemical anomalies. The present study was …