In the adult rodent brain, neural stem cells (NSCs) persist in the ventricular-subventricular
zone (V-SVZ) and the subgranular zone (SGZ), which are specialized niches in which young …

The monoamine hypothesis has been accepted as the most common hypothesis of major
depressive disorder (MDD) for a long period because of its simplicity and understandability …

Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness
and potential impact on cognition but also to its localized vertical integration of different …

Chronic stressful life events are risk factors for developing major depression, the
pathophysiology of which is strongly linked to impairments in serotonin (5-HT) …

We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Increasing evidence points to an association between major depressive disorders (MDDs)
and diverse types of GABAergic deficits. In this review, we summarize clinical and preclinical …

The adult brain is a plastic place. To ensure that the mature nervous system's control of
behaviour is flexible in the face of a varying environment, morphological and physiological …

Cerebral dopamine depletion is the hallmark of Parkinson disease. Because dopamine
modulates ontogenetic neurogenesis, depletion of dopamine might affect neural precursors …

The discovery that the adult mammalian brain creates new neurons from pools of stemlike
cells was a breakthrough in neuroscience. Interestingly, this particular new form of structural …

Antidepressants increase proliferation of neuronal progenitor cells and expression of brain-
derived neurotrophic factor (BDNF) in the hippocampus. We investigated the role of BDNF …