[HTML][HTML] Rodent and fly models in behavioral neuroscience: An evaluation of methodological advances, comparative research, and future perspectives

TC Moulin, LE Covill, PM Itskov, MJ Williams… - Neuroscience & …, 2021 - Elsevier
The assessment of behavioral outcomes is a central component of neuroscientific research,
which has required continuous technological innovations to produce more detailed and …

Supervised and unsupervised learning technology in the study of rodent behavior

KV Gris, JP Coutu, D Gris - Frontiers in behavioral neuroscience, 2017 - frontiersin.org
Quantifying behavior is a challenge for scientists studying neuroscience, ethology,
psychology, pathology, etc. Until now, behavior was mostly considered as qualitative …

A neurodevelopmental origin of behavioral individuality in the Drosophila visual system

GA Linneweber, M Andriatsilavo, SB Dutta… - Science, 2020 - science.org
The genome versus experience dichotomy has dominated understanding of behavioral
individuality. By contrast, the role of nonheritable noise during brain development in …

[HTML][HTML] A paradoxical kind of sleep in Drosophila melanogaster

LAL Tainton-Heap, LC Kirszenblat, ET Notaras… - Current Biology, 2021 - cell.com
The dynamic nature of sleep in many animals suggests distinct stages that serve different
functions. Genetic sleep induction methods in animal models provide a powerful way to …

The 18S ribosomal RNA m6A methyltransferase Mettl5 is required for normal walking behavior in Drosophila

J Leismann, M Spagnuolo, M Pradhan, L Wacheul… - EMBO …, 2020 - embopress.org
RNA modifications have recently emerged as an important layer of gene regulation. N6‐
methyladenosine (m6A) is the most prominent modification on eukaryotic messenger RNA …

[HTML][HTML] Brain connectivity inversely scales with developmental temperature in Drosophila

FR Kiral, SB Dutta, GA Linneweber, S Hilgert, C Poppa… - Cell Reports, 2021 - cell.com
Variability of synapse numbers and partners despite identical genes reveals the limits of
genetic determinism. Here, we use developmental temperature as a non-genetic …

Ethoscopes: An open platform for high-throughput ethomics

Q Geissmann, L Garcia Rodriguez, EJ Beckwith… - PLoS …, 2017 - journals.plos.org
Here, we present the use of ethoscopes, which are machines for high-throughput analysis of
behavior in Drosophila and other animals. Ethoscopes provide a software and hardware …

Culling less fit neurons protects against amyloid-β-induced brain damage and cognitive and motor decline

DS Coelho, S Schwartz, MM Merino, B Hauert, B Topfel… - Cell reports, 2018 - cell.com
Alzheimer's disease (AD) is the most common form of dementia, impairing cognitive and
motor functions. One of the pathological hallmarks of AD is neuronal loss, which is not …

A decision underlies phototaxis in an insect

EA Gorostiza, J Colomb, B Brembs - Open Biology, 2016 - royalsocietypublishing.org
Like a moth into the flame—phototaxis is an iconic example for innate preferences. Such
preferences probably reflect evolutionary adaptations to predictable situations and have …

Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring

FR Kiral, GA Linneweber, T Mathejczyk… - Nature …, 2020 - nature.com
Brain wiring is remarkably precise, yet most neurons readily form synapses with incorrect
partners when given the opportunity. Dynamic axon-dendritic positioning can restrict …