Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis

E D'Amico, P Factor-Litvak, RM Santella… - Free radical biology and …, 2013 - Elsevier
Sporadic amyotrophic lateral sclerosis (ALS) is one of the most devastating neurological
diseases; most patients die within 3 to 4 years after symptom onset. Oxidative stress is a …

Association of pesticide exposure with neurologic dysfunction and disease

F Kamel, JA Hoppin - Environmental health perspectives, 2004 - ehp.niehs.nih.gov
Poisoning by acute high-level exposure to certain pesticides has well-known neurotoxic
effects, but whether chronic exposure to moderate levels of pesticides is also neurotoxic is …

Modulation of paraoxonase (PON1) activity

LG Costa, A Vitalone, TB Cole, CE Furlong - Biochemical pharmacology, 2005 - Elsevier
Paraoxonase 1 (PON1) is a serum enzyme closely associated with high density lipoprotein
(HDL). PON1 hydrolyzes several organophosphorus compounds used as insecticides, as …

Genetic and environmental factors modulating serum concentrations and activities of the antioxidant enzyme paraoxonase-1

SP Deakin, RW James - Clinical Science, 2004 - portlandpress.com
PON1 (paraoxonase-1) is an HDL (high-density lipoprotein)-associated enzyme capable of
hydrolysing diverse substrates from OP (organophosphate) toxins to oxidized phospholipids …

High-density lipoprotein function: recent advances

BJ Ansell, KE Watson, AM Fogelman, M Navab… - Journal of the American …, 2005 - jacc.org
Although high-density lipoproteins (HDL) possess many features that contribute to the
association between elevated HDL cholesterol and protection from atherosclerosis, these …

Assessment of emerging biomarkers of liver injury in human subjects

S Schomaker, R Warner, J Bock, K Johnson… - toxicological …, 2013 - academic.oup.com
Hepatotoxicity remains a major challenge in drug development. Although alanine
aminotransferase (ALT) remains the gold standard biomarker of liver injury, alternative …

Variation in paraoxonase-1 activity and atherosclerosis

H Soran, NN Younis, V Charlton-Menys… - Current opinion in …, 2009 - journals.lww.com
Variation in paraoxonase-1 activity and atherosclerosis : Current Opinion in Lipidology
Variation in paraoxonase-1 activity and atherosclerosis : Current Opinion in Lipidology Log in or …

Modulatory effect of lifestyle-related, environmental and genetic factors on paraoxonase-1 activity: a review

D Kunachowicz, M Ściskalska, M Kepinska - International Journal of …, 2023 - mdpi.com
Paraoxonase-1 (PON1) is a calcium-dependent, HDL-bound serum hydrolase active toward
a wide variety of substrates. PON1 displays three types of activities, among which lactonase …

[HTML][HTML] Effects of aerobic training on serum paraoxonase activity and its relationship with PON1-192 phenotypes in women

GR Nalcakan, SR Varol, F Turgay, M Nalcakan… - Journal of sport and …, 2016 - Elsevier
Abstract Background Paraoxonase 1 (PON1) is an antioxidant enzyme that protects high-
density lipoprotein (HDL) and low-density lipoprotein against oxidation. Limited studies have …

[PDF][PDF] The story of PON1: how an organophosphate-hydrolysing enzyme is becoming a player in cardiovascular medicine

TM Van Himbergen, LJ Van Tits, M Roest… - Neth J Med, 2006 - academia.edu
Van Himbergen, et al. Organophosphate-hydrolysing enzyme in cardiovascular medicine.
tunnel of the enzyme are two calcium atoms needed for the stabilisation of the structure and …