The influence of the histone variant H2A. Z on transcription remains a long-standing
conundrum. Here, by analyzing the actin-related protein6 mutant, which is impaired in H2A …

Nucleosome organization influences gene activity by controlling DNA accessibility to
transcription machinery. Here, we develop a chemical biology approach to determine …

Chromatin remodeling is essential to allow full development of alternative gene expression
programs in response to environmental changes. In fission yeast, oxidative stress triggers …

Despite extensive characterization of mammalian Pol II transcription, the DNA sequence
determinants of transcription initiation at a third of human promoters and most enhancers …

Quiescent cells require a continuous supply of proteins to maintain protein homeostasis. In
fission yeast, entry into quiescence is triggered by nitrogen stress, leading to the inactivation …

It has been postulated that a myriad of long noncoding RNAs (lncRNAs) contribute to gene
regulation. In fission yeast, glucose starvation triggers lncRNA transcription across promoter …

Background Meiotic recombination hotspots control the frequency and distribution of Spo11
(Rec12)-initiated recombination in the genome. Recombination occurs within and is …

Homologous recombination is induced to high levels in meiosis and is clustered at hotspots
that regulate its frequency and distribution in the genome. By studying five different classes …

Transcription factors are often the downstream effectors of signaling cascades. In fission
yeast, the transcription factor Atf1 is phosphorylated by the MAP kinase Sty1 under several …

The MAP kinase Sty1 phosphorylates and activates the transcription factor Atf1 in response
to several stress conditions, which then shifts from a transcriptional repressor to an activator …