Major recent advances and previous data have led to a plausible model of how key proteins
mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive …

During an action potential, Ca 2+ entering a presynaptic terminal triggers synaptic vesicle
exocytosis and neurotransmitter release in less than a millisecond. How does Ca 2+ …

Calcium-dependent exocytosis of synaptic vesicles mediates the release of
neurotransmitters. Important proteins in this process have been identified such as the …

Extensive research has yielded crucial insights into the mechanism of neurotransmitter
release, and working models for the functions of key proteins involved in release. The …

Presynaptic nerve terminals release neurotransmitters by synaptic vesicle exocytosis.
Membrane fusion mediating synaptic exocytosis and other intracellular membrane traffic is …

Research for three decades and major recent advances have provided crucial insights into
how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading …

Neurotransmitter release is governed by proteins that have homo-logs in most types of
intracellular membrane fusion, including the Sec1/Munc18 protein Munc18-1 and the …

During the priming step that leaves synaptic vesicles ready for neurotransmitter release, the
SNARE syntaxin-1 transitions from a closed conformation that binds Munc18-1 tightly to an …

The core of the neurotransmitter release machinery is formed by SNARE complexes, which
bring the vesicle and plasma membranes together and are key for fusion, and by Munc18-1 …

Abstract Mutations in Munc18‐1/STXBP1 (syntaxin‐binding protein 1) are linked to various
severe early epileptic encephalopathies and neurodevelopmental disorders. Heterozygous …