Parasites of the genus Plasmodium, the etiological agent of malaria, are transmitted through
the bite of anopheline mosquitoes, which deposit sporozoites into the host skin. Sporozoites …

An essential step in the life cycle of malaria parasites is their egress from hepatocytes, which
enables the transition from the asymptomatic liver stage to the pathogenic blood stage of …

The O-fucosylation of the thrombospondin type I repeat (TSR) domain is important for TSR-
containing proteins' optimal folding and stability. However, the importance of Plasmodium O …

During macroautophagy, the Atg8 protein is conjugated to phosphatidylethanolamine (PE)
in autophagic membranes. In Apicomplexan parasites, two cysteine proteases, Atg4 and …

Apicomplexa encompasses a large number of intracellular parasites infecting a wide range
of animals. Cyclic nucleotide signaling is crucial for a variety of apicomplexan life stages and …

Plasmodium sporozoites are the infective forms of the malaria parasite in the mosquito and
vertebrate host. Gliding motility allows sporozoites to migrate and invade mosquito salivary …

Merosome development is a very important part of the Plasmodium life cycle. It constitutes
the last step of liver stage development after which merozoites egress to the bloodstream …

The integrity of genomes of the two crucial organelles of the malaria parasite—an apicoplast
and mitochondrion in each cell− must be maintained by DNA repair mediated by proteins …

Plasmodium sporozoites invade hepatocytes, transform into liver stages, and replicate into
thousands of merozoites that infect erythrocytes and cause malaria. Proteins secreted from …

Background Sporozoites isolated from the salivary glands of Plasmodium-infected
mosquitoes are a prerequisite for several basic and pre-clinical applications. Although …