Congenital heart defects constitute the most common human birth defect, however
understanding of how these disorders originate is limited by our ability to model the human …

Organoids capable of forming tissue-like structures have transformed our ability to model
human development and disease. With the notable exception of the human heart, lineage …

Organoids are miniature models of organs to recapitulate spatiotemporal cellular
organization and tissue functionality. The production of organoids has revolutionized the …

Organoids, or miniaturized organs formed in vitro, hold potential to revolutionize how
researchers approach and answer fundamental biological and pathological questions. In the …

The number one cause of human fetal death are defects in heart development. Because the
human embryonic heart is inaccessible and the impacts of mutations, drugs, and …

The endoderm is the cell lineage which gives rise in the embryo to the organs of the
respiratory and gastrointestinal system. In the mouse this may be the germ layer with the …

Cardiac congenital disabilities are the most common organ malformations, but we still do not
understand how they arise in the human embryo. Moreover, although cardiovascular …

Organoids are three-dimensional in vitro cell constructs that recapitulate organ properties
and structure to a significant extent. They constitute particularly useful models to study …

The astounding capacity of pluripotent stem cells (PSCs) to differentiate and self-organize
has revolutionized the development of 3D cell culture models. The major advantage is its …

Cardiac fibroblasts (CFBs) support heart function by secreting extracellular matrix (ECM)
and paracrine factors, respond to stress associated with injury and disease, and therefore …