As we drink and breathe: Adverse health effects of microcystins and other harmful algal bloom toxins in the liver, gut, lungs and beyond

A Lad, JD Breidenbach, RC Su, J Murray, R Kuang… - Life, 2022 - mdpi.com
Freshwater harmful algal blooms (HABs) are increasing in number and severity worldwide.
These HABs are chiefly composed of one or more species of cyanobacteria, also known as …

[HTML][HTML] Effects of environmental contaminants in water resources on nonalcoholic fatty liver disease

S Zheng, Y Yang, C Wen, W Liu, L Cao, X Feng… - Environment …, 2021 - Elsevier
The global prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing
rapidly in recent years, which is now estimated to be over 25%. NAFLD is one of the most …

Identification of Novel Microcystins Using High-Resolution MS and MSn with Python Code

D Baliu-Rodriguez, NJ Peraino… - Environmental …, 2022 - ACS Publications
Cyanotoxins called microcystins (MCs) are highly toxic and can be present in drinking water
sources. Determining the structure of MCs is paramount because of its effect on toxicity …

Cyanobacterial Harmful Algal Bloom Toxin Microcystin and Increased Vibrio Occurrence as Climate-Change-Induced Biological Co-Stressors: Exposure and Disease …

S Chatterjee, M More - Toxins, 2023 - mdpi.com
The effects of global warming are not limited to rising global temperatures and have set in
motion a complex chain of events contributing to climate change. A consequence of global …

Advances in investigating microcystin-induced liver toxicity and underlying mechanisms

T Li, X Fan, M Cai, Y Jiang, Y Wang, P He, J Ni… - Science of The Total …, 2023 - Elsevier
Microcystins (MCs) are a class of biologically active cyclic heptapeptide pollutants produced
by the freshwater alga Microcystis aeruginosa. With increased environmental pollution, MCs …

[HTML][HTML] Chronic exposure to low concentration of MC-LR caused hepatic lipid metabolism disorder

C Du, S Zheng, Y Yang, X Feng, J Chen, Y Tang… - Ecotoxicology and …, 2022 - Elsevier
Abstract Microcystin-LR (MC-LR), a potent hepatotoxin can cause liver damages. However,
research on hepatic lipid metabolism caused by long-term exposure to environmental …

A new identity of microcystins: Environmental endocrine disruptors? An evidence-based review

S Zhang, H Liu, X Du, X Chen, P Petlulu, Z Tian… - Science of The Total …, 2022 - Elsevier
Microcystins (MCs) are widely distributed cyanobacterial toxins in eutrophic waters. At
present, the endocrine-disrupting effects of MCs have been extensively studied, but whether …

[HTML][HTML] Long-term environmental exposure to microcystins increases the risk of nonalcoholic fatty liver disease in humans: A combined fisher-based investigation and …

Y Zhao, Y Yan, L Xie, L Wang, Y He, X Wan… - Environment …, 2020 - Elsevier
Microcystins (MCs) produced by cyanobacteria pose serious threats to human health.
However, the contribution of long-term exposure to MCs to the development of nonalcoholic …

Cyanotoxins increase cytotoxicity and promote nonalcoholic fatty liver disease progression by enhancing cell steatosis

S Niture, S Gadi, Q Qi, L Rios-Colon, S Khatiwada… - Toxins, 2023 - mdpi.com
Freshwater prokaryotic cyanobacteria within harmful algal blooms produce cyanotoxins
which are considered major pollutants in the aquatic system. Direct exposure to cyanotoxins …

MC-LR aggravates liver lipid metabolism disorders in obese mice fed a high-fat diet via PI3K/AKT/mTOR/SREBP1 signaling pathway

H Chu, C Du, Y Yang, X Feng, L Zhu, J Chen, F Yang - Toxins, 2022 - mdpi.com
Obesity, a metabolic disease caused by excessive fat accumulation in the body, has
attracted worldwide attention. Microcystin-LR (MC-LR) is a hepatotoxic cyanotoxin which …