Melatonin and myo-inositol: Supporting reproduction from the oocyte to birth

M Russo, G Forte, M Montanino Oliva… - International journal of …, 2021 - mdpi.com
Human pregnancy is a sequence of events finely tuned by several molecular interactions
that come with a new birth. The precise interlocking of these events affecting the …

Insights into potential targets for therapeutic intervention in epilepsy

C Zavala-Tecuapetla, M Cuellar-Herrera… - International journal of …, 2020 - mdpi.com
Epilepsy is a chronic brain disease that affects approximately 65 million people worldwide.
However, despite the continuous development of antiepileptic drugs, over 30% patients with …

Melatonin attenuates oxidative stress-induced apoptosis of bovine ovarian granulosa cells by promoting mitophagy via SIRT1/FoxO1 signaling pathway

G Xu, Y Dong, Z Wang, H Ding, J Wang, J Zhao… - International Journal of …, 2023 - mdpi.com
Oxidative-stress-induced apoptosis of granulosa cells is considered to be a main driver of
follicular atresia. Increasing evidence suggests a protective effect of melatonin against …

Melatonin or L-arginine in semen extender mitigate reductions in quality of frozen-thawed sperm from heat-stressed rams

AM Shahat, JC Thundathil, JP Kastelic - Animal Reproduction Science, 2022 - Elsevier
Our objective was to determine effects of melatonin or L-arginine on quality of frozen-thawed
sperm from heat-stressed (HS) rams. Ten Dorset rams were randomly allocated to either …

Melatonin promotes the growth and development of lambs by increasing growth hormone and testosterone, targeting on apoptosis signaling pathway and intestinal …

W Ma, H Wu, G Li, L Yan, L Wang, M Zhao… - Frontiers in …, 2022 - frontiersin.org
Melatonin is an indole-like neuroendocrine hormone. A large number of studies have shown
that melatonin can improve production performance of ewes, but it is not clear in lambs. In …

Anabolism and signaling pathways of phytomelatonin

Y Liu, X Wang, H Lv, M Cao, Y Li, X Yuan… - Journal of …, 2022 - academic.oup.com
Phytomelatonin is a small multifunctional molecule found ubiquitously in plants, which plays
an important role in plant growth, development, and biotic and abiotic stress responses. The …

[HTML][HTML] Melatonin regulates the ovarian function and enhances follicle growth in aging laying hens via activating the mammalian target of rapamycin pathway

E Hao, H Chen, DH Wang, C Huang, Y Tong, Y Chen… - Poultry science, 2020 - Elsevier
The signal pathway of target of rapamycin (TOR) plays an important role in regulating cell
growth and proliferation, follicular development, and ovulation. Melatonin (N-acetyl-5 …

Effects of melatonin administration to pregnant ewes under heat-stress conditions, in redox status and reproductive outcome

E Bouroutzika, D Kouretas, S Papadopoulos… - Antioxidants, 2020 - mdpi.com
Heat stress is a known promoter of reactive oxygen species generation, which may
compromise pregnancy and foetal development. Melatonin is a pleiotropic molecule that …

Melatonin alleviates the toxic effect of di (2-ethylhexyl) phthalate on oocyte quality resulting from CEBPB suppression during primordial follicle formation

JJ Wang, XY Zhang, Y Zeng, QC Liu, XL Feng… - Journal of Hazardous …, 2024 - Elsevier
Presently, the exposure of plasticizers to humans and animals occurs daily, which pose a
potential threat to reproductive health. In the present study, a pregnant mouse model …

Melatonin and insulin modulates the cellular biochemistry, histoarchitecture and receptor expression during hepatic injury in diabetic rats

YA Hajam, S Rai - Life sciences, 2019 - Elsevier
Aims; The present study was designed to ameliorate the integrated efficacy of exogenous
melatonin and insulin on tissue biochemical, serological, histopathological architecture and …