Microbial secondary metabolites (MSMs) have played and continue to play a highly
significant role in the drug discovery and development process. Genetically, MSM chemical …

Genomic analysis has demonstrated that many fungi possess essential gene clusters for the
production of previously unobserved secondary metabolites; however, these genes are …

Covering: 2014 up to the third quarter of 2019 Entomopathogens constitute a unique,
specialized trophic subgroup of fungi, most of whose members belong to the order …

Plant microbiomes are not only diverse, but also appear to host a vast pool of secondary
metabolites holding great promise for bioactive natural products and drug discovery. Yet …

The addition of a DNA methyltransferase inhibitor, 5-azacytidine, to Aspergillus sydowii
fungus culture broth changed its secondary metabolites profile. Analysis of the culture broth …

Microbial secondary metabolites are pivotal for the development of novel drugs. However,
conventional culture techniques, have left a vast array of unexpressed biosynthetic gene …

Attenuating the Taxol productivity of fungi with the subculturing and storage under axenic
conditions is the challenge that halts the feasibility of fungi to be an industrial platform for …

Fungi usually contain gene clusters that are silent or cryptic under normal laboratory culture
conditions. These cryptic genes could be expressed for a wide variety of bioactive …

A mangrove endophytic fungus Phomopsis asparagi DHS-48 was found to be particularly
productive with regard to the accumulation of substantial new compounds in our previous …

The addition of the histone deacetylase inhibitor suberoylanilide hydroxamic acid to a
culture of the filamentous fungus Beauveria felina significantly changed its secondary …