Mitochondrial DNA replication is an essential process in most eukaryotes. Similar to the
diversity in mitochondrial genome size and organization in the different eukaryotic …

Linking, or multicomponent topological entanglement, is ubiquitous in soft matter systems,
from mixtures of polymers and DNA filaments packed in vivo to interlocked line defects in …

Kinetoplast DNA (kDNA) is a two-dimensional Olympic-ring-like network of mutually linked
DNA minicircles found in certain parasites called trypanosomes. Understanding the self …

The three dimensional organization of genomes remains mostly unknown due to their high
degree of condensation. Biophysical studies predict that condensation promotes the …

The kinetoplast DNA (kDNA) is the archetype of a two-dimensional Olympic network,
composed of thousands of DNA minicircles and found in the mitochondrion of certain …

In this work we present a computational study of the kinetoplast genome, modelled as a
large number of semiflexible unknotted loops, which are allowed to link with each other. As …

All life forms are miraculous, but some are more inexplicable than others. Trypanosomes are
by far one of the most puzzling organisms on Earth: their mitochondrial genome, also called …

Trypanosoma cruzi causes Chagas disease and has a unique extranuclear genome
enclosed in a structure called the kinetoplast, which contains circular genomes known as …

Inspired by experiments on topologically linked DNA networks, we consider the connectivity
of Borromean networks, in which no two rings share a pairwise-link, but groups of three rings …

Kinetoplast DNA (kDNA), a unique mitochondrial structure common to trypanosomatid
parasites, contains thousands of DNA minicircles that are densely packed and can be …