Circulating endocannabinoids: from whence do they come and where are they going?

CJ Hillard - Neuropsychopharmacology, 2018 - nature.com
The goal of this review is to summarize studies in which concentrations of circulating
endocannabinoids in humans have been examined in relationship to physiological …

From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology

A Ligresti, L De Petrocellis… - Physiological …, 2016 - journals.physiology.org
Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders

C Silvestri, V Di Marzo - Cell metabolism, 2013 - cell.com
Endocannabinoids and cannabinoid CB1 receptors are known to play a generalized role in
energy homeostasis. However, clinical trials with the first generation of CB1 blockers, now …

Cannabinoid receptors: An update on cell signaling, pathophysiological roles and therapeutic opportunities in neurological, cardiovascular, and inflammatory …

D Haspula, MA Clark - International journal of molecular sciences, 2020 - mdpi.com
The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …

Obesity: Current and potential pharmacotherapeutics and targets

V Narayanaswami, LP Dwoskin - Pharmacology & therapeutics, 2017 - Elsevier
Obesity is a global epidemic that contributes to a number of health complications including
cardiovascular disease, type 2 diabetes, cancer and neuropsychiatric disorders …

Psychometric analysis of the Three-Factor Eating Questionnaire-R21: results from a large diverse sample of obese and non-obese participants

JC Cappelleri, AG Bushmakin, RA Gerber… - International journal of …, 2009 - nature.com
Background: The 21-item Three-Factor Eating Questionnaire (TFEQ-R21) is a scale that
measures three domains of eating behavior: cognitive restraint (CR), uncontrolled eating …

Impact of dietary fats on brain functions

R Chianese, R Coccurello, A Viggiano… - Current …, 2018 - ingentaconnect.com
Background: Adequate dietary intake and nutritional status have important effects on brain
functions and on brain health. Energy intake and specific nutrients excess or deficiency from …

Sleep restriction enhances the daily rhythm of circulating levels of endocannabinoid 2-arachidonoylglycerol

EC Hanlon, E Tasali, R Leproult, KL Stuhr, E Doncheck… - Sleep, 2016 - academic.oup.com
Abstract Study Objectives: Increasing evidence from laboratory and epidemiologic studies
indicates that insufficient sleep may be a risk factor for obesity. Sleep curtailment results in …

Endocannabinoid regulation of reward and reinforcement through interaction with dopamine and endogenous opioid signaling

JM Wenzel, JF Cheer - Neuropsychopharmacology, 2018 - nature.com
The endocannabinoid system (eCB) is implicated in the mediation of both reward and
reinforcement. This is evidenced by the ability of exogenous cannabinoid drugs to produce …

CNS regulation of appetite

JA Harrold, TM Dovey, JE Blundell, JCG Halford - Neuropharmacology, 2012 - Elsevier
This article reviews the regulation of appetite from a biopsychological perspective. It
considers psychological experiences and peripheral nutritional systems (both episodic and …