Senataxin ortholog Sen1 limits DNA: RNA hybrid accumulation at DNA double-strand breaks to control end resection and repair fidelity
CC Rawal, L Zardoni, M Di Terlizzi, E Galati… - Cell reports, 2020 - cell.com
An important but still enigmatic function of DNA: RNA hybrids is their role in DNA double-
strand break (DSB) repair. Here, we show that Sen1, the budding yeast ortholog of the …
strand break (DSB) repair. Here, we show that Sen1, the budding yeast ortholog of the …
Rad9/53BP1 promotes DNA repair via crossover recombination by limiting the Sgs1 and Mph1 helicases
The DNA damage checkpoint (DDC) is often robustly activated during the homologous
recombination (HR) repair of DNA double strand breaks (DSBs). DDC activation controls …
recombination (HR) repair of DNA double strand breaks (DSBs). DDC activation controls …
Structure-forming CAG/CTG repeats interfere with gap repair to cause repeat expansions and chromosome breaks
EJ Polleys, I Del Priore, JE Haber… - Nature …, 2023 - nature.com
Expanded CAG/CTG repeats are sites of DNA damage, leading to repeat length changes.
Homologous recombination (HR) is one cause of repeat instability and we hypothesized that …
Homologous recombination (HR) is one cause of repeat instability and we hypothesized that …
Saccharomyces cerevisiae Rev7 promotes non-homologous end-joining by blocking Mre11 nuclease and Rad50's ATPase activities and homologous recombination
S Badugu, KM Dhyani, M Thakur, K Muniyappa - eLife, 2024 - elifesciences.org
Recent studies have shown that, in human cancer cells, the tetrameric Shieldin complex
(comprising REV7, SHLD1, SHLD2, and SHLD3) facilitates non-homologous end-joining …
(comprising REV7, SHLD1, SHLD2, and SHLD3) facilitates non-homologous end-joining …
Yeast Nat4 regulates DNA damage checkpoint signaling through its N-terminal acetyltransferase activity on histone H4
M Constantinou, E Charidemou, I Shanlitourk… - PLoS …, 2024 - journals.plos.org
The DNA damage response (DDR) constitutes a vital cellular process that safeguards
genome integrity. This biological process involves substantial alterations in chromatin …
genome integrity. This biological process involves substantial alterations in chromatin …
Formation and nucleolytic processing of Cas9-induced DNA breaks in human cells quantified by droplet digital PCR
Cas9 endonuclease from S. pyogenes is widely used to induce controlled double strand
breaks (DSB) at desired genomic loci for gene editing. Here, we describe a droplet digital …
breaks (DSB) at desired genomic loci for gene editing. Here, we describe a droplet digital …
Saccharomyces cerevisiae Rev7 promotes non-homologous end-joining by blocking Mre11 nuclease and Rad50's ATPase activities and homologous recombination
S Badugu, KM Dhyani, M Thakur, K Muniyappa - bioRxiv, 2024 - biorxiv.org
Recent studies have shown that, in human cancer cells, the tetrameric Shieldin complex
(comprising REV7, SHLD1, SHLD2, and SHLD3) facilitates non-homologous end-joining …
(comprising REV7, SHLD1, SHLD2, and SHLD3) facilitates non-homologous end-joining …
Characterization of the Mechanistic Roles of Rif1-Glc7 in DNA Double-Strand Break Repair Pathway Choice in Saccharomyces cerevisiae
R Quinn - 2023 - uwspace.uwaterloo.ca
Rap-1 interacting factor 1 (Rif1) is a protein involved in telomere regulation, DNA replication
and has more recently been found to mediate genomic stability by influencing the choice of …
and has more recently been found to mediate genomic stability by influencing the choice of …
Rad9/53BP1 promotes crossover recombination DNA repair by limiting the Sgs1 and Mph1 helicases
M Ferrari, CC Rawal, S Lodovichi, A Pellicioli - bioRxiv, 2019 - biorxiv.org
A DNA double strand break (DSB) is primed for homologous recombination (HR) repair
through the nucleolytic processing (resection) of its ends, leading to the formation of a 3 …
through the nucleolytic processing (resection) of its ends, leading to the formation of a 3 …