The role of endocrine disruptors bisphenols and phthalates in obesity: current evidence, perspectives and controversies

M Dalamaga, D Kounatidis, D Tsilingiris… - International Journal of …, 2024 - mdpi.com
Excess body weight constitutes one of the major health challenges for societies and
healthcare systems worldwide. Besides the type of diet, calorie intake and the lack of …

[HTML][HTML] Novel drugs affecting diabetic peripheral neuropathy

DO Saleh, AA Sedik - Iranian Journal of Basic Medical Sciences, 2024 - ncbi.nlm.nih.gov
Diabetic peripheral neuropathy (DPN) poses a significant threat, affecting half of the global
diabetic population and leading to severe complications, including pain, impaired mobility …

Mitigating effect of ferulic acid on di-(2-ethylhexyl) phthalate-induced neurocognitive dysfunction in male rats with a comprehensive in silico survey

M Khalifa, RH Fayed, YH Ahmed, AA Sedik… - Naunyn-schmiedeberg's …, 2024 - Springer
Abstract Di-(2-ethylhexyl) phthalate (DEHP) is the most abundant phthalate threatening
public health-induced neurotoxicity. This neurotoxicity is associated with behavioral and …

Ovario- protective effect of Moringa oleifera leaf extract against cyclophosphamide-induced oxidative ovarian damage and reproductive dysfunction in female rats

SS Soliman, AA Suliman, K Fathy, AA Sedik - Scientific Reports, 2025 - nature.com
It is crucial to develop new tactics to prevent ovarian tissue damage in women whose
reproductive toxicity is caused by chemotherapy. The present investigation was performed to …

Quercetin antagonizes apoptosis, autophagy and immune dysfunction induced by di (2-ethylhexyl) phthalate via ROS/ASK1/JNK pathway

J Sun, X Wang, T Xu, M Ren, M Gao, H Lin - Comparative Biochemistry and …, 2024 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a plasticizer that can damage various
organizations and physiques through oxidative stress. Quercetin (Que) is a rich polyphenol …

Neuroprotective and cognitive enhancing effects of herbecetin against thioacetamide induced hepatic encephalopathy in rats via upregulation of AMPK and SIRT1 …

AA Sedik, DT Hussein, K Fathy, NA Mowaad - Scientific Reports, 2024 - nature.com
Acute liver injury, there is a risky neurological condition known as hepatic encephalopathy
(HE). Herbacetin is a glycosylated flavonoid with many pharmacological characteristics. The …

Neuromodulatory role of L-arginine: Nitric oxide precursor against thioacetamide-induced-hepatic encephalopathy in rats via downregulation of NF-κB-mediated …

AA Sedik, A Hassan, DO Saleh - Environmental Science and Pollution …, 2023 - Springer
The aim of the present study was to investigate the impact of arginine (ARG), a nitric oxide
(NO) precursor, on thioacetamide (TAA)-induced hepatic encephalopathy (HE) in rats by …

Phthalates Induced Neurotoxicity: A Mechanistic Approach

K Gaur, YH Siddique - Central Nervous System Agents in …, 2024 - benthamdirect.com
Phthalates play a significant role as plastic modifying additives in everyday items like
plastics, pesticides, paints, and cosmetics. This review explores the relationship between …