The Eph receptor tyrosine kinases and their ephrin ligands have intriguing expression
patterns in cancer cells and tumour blood vessels, which suggest important roles for their …

Critical roles for EPH receptor (EPH)–ephrin signalling in a range of chronic and
regenerative diseases are increasingly being recognized. In particular, the complex roles of …

The development, homeostasis, and regeneration of complex organ systems require
extensive cell–cell communication to ensure that different cells proliferate, migrate …

The evolution of colorectal cancer suggests the involvement of many genes. To identify new
drivers of intestinal cancer, we performed insertional mutagenesis using the Sleeping …

Eph receptor tyrosine kinases play critical functions during development, in the formation of
tissue and organ borders, and the vascular and neural systems. Uniquely among tyrosine …

Eph receptor tyrosine kinases and their Ephrin ligands represent an important signaling
system with widespread roles in cell physiology and disease. Receptors and ligands in this …

Abstract Background The EphB4 receptor tyrosine kinase is overexpressed in many cancers
including prostate cancer. The molecular mechanisms by which this ephrin receptor …

Activation of the small GTPase RHOA has strong oncogenic effects in many tumour types,
although its role in colorectal cancer remains unclear. Here we show that RHOA inactivation …

EphB4 and its cognitive ligand ephrinB2 play an important role in embryonic vessel
development and vascular remodeling. In addition, several reports suggest that this receptor …

Numerous studies attest to essential roles for Eph receptors and their ephrin ligands in
controlling cell positioning and tissue patterning during normal and oncogenic development …