Chronic pancreatitis is defined as a pathological fibro-inflammatory syndrome of the
pancreas in individuals with genetic, environmental and/or other risk factors who develop …

Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …

Background & Aims Pancreatitis starts with primarily sterile local inflammation that induces
systemic inflammatory response syndrome, followed by compensatory anti-inflammatory …

Background & Aims Acute pancreatitis is characterized by premature intracellular activation
of digestive proteases within pancreatic acini and a consecutive systemic inflammatory …

Elevated pressure in the pancreatic gland is the central cause of pancreatitis following
abdominal trauma, surgery, endoscopic retrograde cholangiopancreatography, and …

Chronic pancreatitis is characterized by progressive, irreversible morphologic and functional
changes that are most commonly attributed to environmental insults, particularly when there …

Pancreatic fibrosis is a complication of chronic pancreatitis and is a prominent feature of
pancreatic cancer. Pancreatic fibrosis is commonly observed in patients with prolonged …

Background & Aims Pancreatic ductal adenocarcinomas (PDACs) are characterized by
fibrosis and an abundance of cancer-associated fibroblasts (CAFs). We investigated …

Chronic pancreatitis (CP) is characterized by chronic inflammation and the progressive
fibrotic replacement of exocrine and endocrine pancreatic tissue. We identify Treg cells as …

Background We previously reported higher plasma levels of complement fragments C3a
and C5a in neovascular Age-related Macular Degeneration (nAMD) patients with macular …