A single gene yields many forms of proteins via combinations of posttranscriptional/ posttranslational modifications. Proteins also fold into higher‐order structures and interact …
The rapid spread of drug-resistant pathogens and the declining discovery of new antibiotics have created a global health crisis and heightened interest in the search for novel …
Native mass spectrometry (nMS) is one of the most powerful biophysical methods for the direct observation of noncovalent protein interactions with both small molecules and other …
Native mass spectrometry (nMS) is a biophysical method for studying protein complexes and can provide insights into subunit stoichiometry and composition, protein–ligand, and protein …
A Oluwole, D Shutin, JR Bolla - Essays in Biochemistry, 2023 - portlandpress.com
Integral membrane proteins are involved in a plethora of biological processes including cellular signalling, molecular transport, and catalysis. Many of these functions are mediated …
K Sokratous, DA Cooper-Shepherd… - Journal of the …, 2024 - ACS Publications
Native mass spectrometry (MS) is proving to be a disruptive technique for studying the interactions of proteins, necessary for understanding the functional roles of these …
D Favre, JF Harmon, A Zhang, MS Miller… - Journal of Inorganic …, 2022 - Elsevier
Polyoxidometalates (POMs) exhibit a range of biological properties that can be exploited for a variety of therapeutic applications. However, their potential utility as antivirals has been …
Viroporins constitute a class of viral membrane proteins with diverse roles in the viral life cycle. They can self-assemble and form pores within the bilayer that transport substrates …
B Russell Lewis, R Lawrence… - Essays in …, 2023 - portlandpress.com
Multidrug efflux pumps are ubiquitous across both eukaryotes and prokaryotes, and have major implications in antimicrobial and multidrug resistance. They reside within cellular …