Parkinson's disease is the second most common neurodegenerative disease and yet the
early pathophysiological events of the condition and sequences of dysfunction remain …

Parkinson's disease (PD) is a neurodegenerative disorder for which there is no cure. Most
patients suffer from sporadic PD, which is likely caused by a combination of genetic and …

The etiology of Parkinson's disease (PD) is not well understood but likely to involve both
genetic and environmental factors. Incidence and prevalence estimates vary to a large …

Background A Task Force was convened by the EFNS/MDS‐ES Scientist Panel on P
arkinson's disease (PD) and other movement disorders to systemically review relevant …

Parkinson disease (PD) is a multifactorial neurodegenerative disease that was long
considered the result of environmental factors. In the past 15 years, however, a genetic …

Oxidative stress contributes to the cascade leading to dopamine cell degeneration in
Parkinson's disease (PD). However, oxidative stress is intimately linked to other components …

Background Mutations in the parkin gene have recently been identified in patients with early-
onset Parkinson's disease, but the frequency of the mutations and the associated phenotype …

The correct diagnosis of Parkinson's disease is important for prognostic and therapeutic
reasons and is essential for clinical research. Investigations of the diagnostic accuracy for …

Although the causes of Parkinson's disease (PD) are thought to be primarily environmental,
recent studies suggest that a number of genes influence susceptibility. Using targeted case …

Less than a quarter century after the discovery of SNCA as the first attributable gene in
Parkinson's disease (PD), our knowledge of the genetic architecture underlying this disease …