The dark side of lipid metabolism in prostate and renal carcinoma: novel insights into molecular diagnostic and biomarker discovery

NA di Meo, F Lasorsa, M Rutigliano… - Expert Review of …, 2023 - Taylor & Francis
Introduction Lipidomics focuses on the in-depth analysis of lipids, which are crucial
macromolecules involved in a wide range of metabolic pathways. The increased …

[HTML][HTML] Influence of cholesterol on cancer progression and therapy

SS Mayengbam, A Singh, AD Pillai, MK Bhat - Translational oncology, 2021 - Elsevier
Cholesterol is a fundamental molecule necessary for the maintenance of cell structure and is
vital to various normal biological functions. It is a key factor in lifestyle-related diseases …

Cholesterol: An important actor on the cancer immune scene

H Halimi, S Farjadian - Frontiers in Immunology, 2022 - frontiersin.org
Based on the structural and signaling roles of cholesterol, which are necessary for immune
cell activity, high concentrations of cholesterol and its metabolites not only trigger malignant …

LDL, HDL and endocrine-related cancer: From pathogenic mechanisms to therapies

G Revilla, L Cedó, M Tondo, A Moral, JI Pérez… - Seminars in cancer …, 2021 - Elsevier
Cholesterol is essential for a variety of functions in endocrine-related cells, including
hormone and steroid production. We have reviewed the progress to date in research on the …

Cholesterol induces epithelial-to-mesenchymal transition of prostate cancer cells by suppressing degradation of EGFR through APMAP

S Jiang, X Wang, D Song, XJ Liu, Y Gu, Z Xu, X Wang… - Cancer research, 2019 - AACR
Cholesterol increases the risk of aggressive prostate cancer and has emerged as a potential
therapeutic target for prostate cancer. The functional roles of cholesterol in prostate cancer …

Cholesterol homeostasis and cancer: a new perspective on the low-density lipoprotein receptor

J Gu, N Zhu, HF Li, TJ Zhao, CJ Zhang, DF Liao, L Qin - Cellular Oncology, 2022 - Springer
Background Disturbance of cholesterol homeostasis is considered as one of the
manifestations of cancer. Cholesterol plays an essential role in the pleiotropic functions of …

The evolving landscape of PCSK9 inhibition in cancer

PP Oza, K Kashfi - European journal of pharmacology, 2023 - Elsevier
Cancer is a disease with a significant global burden in terms of premature mortality, loss of
productivity, healthcare expenditures, and impact on mental health. Recent decades have …

Prostate cancer—Focus on cholesterol

L Škara, A Huđek Turković, I Pezelj, A Vrtarić, N Sinčić… - Cancers, 2021 - mdpi.com
Simple Summary Prostate cancer presents a significant global public health burden. One of
its established risk factors is high fat diet. It has been proven that cholesterol levels in blood …

Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells

SS Mayengbam, A Singh, H Yaduvanshi, FK Bhati… - Cancer & …, 2023 - Springer
Hypercholesterolemia is often correlated with obesity which is considered a risk factor for
various cancers. With the growing population of hypercholesterolemic individuals, there is a …

Intratumoral restoration of miR-137 plus cholesterol favors homeostasis of the miR-137/coactivator p160/AR axis and negatively modulates tumor progression in …

R Pimenta, CM Mioshi, GL Gonçalves… - International journal of …, 2023 - mdpi.com
MicroRNAs (miRNAs) have gained a prominent role as biomarkers in prostate cancer (PCa).
Our study aimed to evaluate the potential suppressive effect of miR-137 in a model of …