Human ratings of conceptual disorganization, poverty of content, referential cohesion and
illogical thinking have been shown to predict psychosis onset in prospective clinical high risk …

Cognitive impairment is a core feature of schizophrenia and a major contributor to poor
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …

Importance Although clinical criteria for identifying youth at risk for psychosis have been
validated, they are not sufficiently accurate for predicting outcomes to inform major treatment …

Converging evidence implicates redox dysregulation as a pathological mechanism driving
the emergence of psychosis. Increased oxidative damage and decreased capacity of …

Background This study aimed to examine whether 40-Hz auditory steady-state responses
(ASSRs) are impaired in participants at clinical high-risk for psychosis (CHR-P) and predict …

New treatment development for psychiatric disorders depends critically upon the
development of physiological measures that can accurately translate between preclinical …

Over the past 20 years there has been a great deal of research into those considered to be
at risk for developing psychosis. Much has been learned and studies have been …

Alternatives to traditional categorical diagnoses have been proposed to improve the validity
and utility of psychiatric nosology. This paper continues the companion review of an …

Schizophrenia is a major mental disorder that affects approximately 1% of the population
worldwide. Cognitive deficits are a key feature of the disorder and a primary cause of long …

Current silo-based diagnostic systems for mental disorders lack utility and fail to fulfil a
fundamental purpose of diagnosis: to guide treatment planning and predict outcomes …