Recent progress in non-native nucleic acid modifications
While Nature harnesses RNA and DNA to store, read and write genetic information, the
inherent programmability, synthetic accessibility and wide functionality of these nucleic acids …
inherent programmability, synthetic accessibility and wide functionality of these nucleic acids …
Structure, properties, and biological relevance of the DNA and RNA G-quadruplexes: Overview 50 years after their discovery
NG Dolinnaya, AM Ogloblina, MG Yakubovskaya - Biochemistry (Moscow), 2016 - Springer
Abstract G-quadruplexes (G4s), which are known to have important roles in regulation of key
biological processes in both normal and pathological cells, are the most actively studied non …
biological processes in both normal and pathological cells, are the most actively studied non …
Small molecule–RNA targeting: starting with the fundamentals
AE Hargrove - Chemical Communications, 2020 - pubs.rsc.org
The structural and regulatory elements in therapeutically relevant RNAs offer many
opportunities for targeting by small molecules, yet fundamental understanding of what drives …
opportunities for targeting by small molecules, yet fundamental understanding of what drives …
Microenvironment-sensitive fluorescent nucleotide probes from benzofuran, benzothiophene, and selenophene as substrates for DNA polymerases
P Ghosh, HM Kropp, K Betz, S Ludmann… - Journal of the …, 2022 - ACS Publications
DNA polymerases can process a wide variety of structurally diverse nucleotide substrates,
but the molecular basis by which the analogs are processed is not completely understood …
but the molecular basis by which the analogs are processed is not completely understood …
A modular aldol approach for internal fluorescent molecular rotor chalcone surrogates for DNA biosensing applications
RE Johnson, MT Murray, LJ Bycraft, SD Wetmore… - Chemical …, 2023 - pubs.rsc.org
Fluorescent molecular rotors (FMRs) are critical tools for probing nucleic acid structure and
function. Many valuable FMRs have been incorporated into oligonucleotides, although the …
function. Many valuable FMRs have been incorporated into oligonucleotides, although the …
A dual-app nucleoside probe provides structural insights into the human telomeric overhang in live cells
Understanding the topology adopted by individual G-quadruplex (GQ)-forming sequences in
vivo and targeting a specific GQ motif among others in the genome will have a profound …
vivo and targeting a specific GQ motif among others in the genome will have a profound …
Fluorescence turn-on sensing of DNA duplex formation by a tricyclic cytidine analogue
DD Burns, KL Teppang, RW Lee… - Journal of the …, 2017 - ACS Publications
Most fluorescent nucleoside analogues are quenched when base stacked and some
maintain their brightness, but there has been little progress toward developing nucleoside …
maintain their brightness, but there has been little progress toward developing nucleoside …
Multicharged phthalocyanines as selective ligands for G-quadruplex DNA structures
The stabilization of G-Quadruplex DNA structures by ligands is a promising strategy for
telomerase inhibition in cancer therapy since this enzyme is responsible for the unlimited …
telomerase inhibition in cancer therapy since this enzyme is responsible for the unlimited …
Post-transcriptional labeling by using Suzuki–Miyaura cross-coupling generates functional RNA probes
Pd-catalyzed CC bond formation, an important vertebra in the spine of synthetic chemistry, is
emerging as a valuable chemoselective transformation for post-synthetic functionalization of …
emerging as a valuable chemoselective transformation for post-synthetic functionalization of …
Small molecule-based pattern recognition to classify RNA structure
Three-dimensional RNA structures are notoriously difficult to determine, and the link
between secondary structure and RNA conformation is only beginning to be understood …
between secondary structure and RNA conformation is only beginning to be understood …