The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

Patterns of transcriptional activity are encoded in our genome through regulatory elements
such as promoters or enhancers that, paradoxically, contain similar assortments of …

Curcumin is known as a natural dietary polyphenol which is extracted from Curcuma longa
L. It has been shown that curcumin has a variety of pharmacological effects such as …

A 30-amino-acid segment of C/EBP, a newly discovered enhancer binding protein, shares
notable sequence similarity with a segment of the cellular Myc transforming protein. Display …

DNA methylation is the most studied epigenetic modification, capable of controlling gene
expression in the contexts of normal traits or diseases. It is highly dynamic during early …

The combinatorial cross-regulation of hundreds of sequence-specific transcription factors
(TFs) defines a regulatory network that underlies cellular identity and function. Here we use …

We have isolated a cDNA clone encoding a novel helixloophdix (HLH) protein, Id. Id is
missing the basic region adjacent to the HLH domain that is essential for specific DNA …

The cloning of genes encoding mammalian DNA binding transcription factors for RNA
polymerase II has provided the opportunity to analyze the structure and function of these …

Most chronic diseases, caused by lifestyle factors, appear to be linked to inflammation.
Inflammation is activated mechanistically, and nuclear factor-κB (NF-κB) is a significant …