RET in breast cancer: functional and therapeutic implications
A Morandi, I Plaza-Menacho, CM Isacke - Trends in molecular medicine, 2011 - cell.com
Recent studies demonstrate that the receptor tyrosine kinase RET is overexpressed in a
subset of ER-positive breast cancers and that crosstalk between RET and ER is important in …
subset of ER-positive breast cancers and that crosstalk between RET and ER is important in …
[HTML][HTML] The GDNF family: a role in cancer?
The glial cell line–derived neurotrophic factor (GDNF) family of ligands (GFLs) comprising of
GDNF, neurturin, artemin, and persephin plays an important role in the development and …
GDNF, neurturin, artemin, and persephin plays an important role in the development and …
Identification of a cytokine-dominated immunosuppressive class in squamous cell lung carcinoma with implications for immunotherapy resistance
M Yang, C Lin, Y Wang, K Chen, H Zhang, W Li - Genome Medicine, 2022 - Springer
Background Immune checkpoint blockade (ICB) therapy has revolutionized the treatment of
lung squamous cell carcinoma (LUSC). However, a significant proportion of patients with …
lung squamous cell carcinoma (LUSC). However, a significant proportion of patients with …
RET is a potential tumor suppressor gene in colorectal cancer
Y Luo, KD Tsuchiya, D Il Park, R Fausel, S Kanngurn… - Oncogene, 2013 - nature.com
Cancer arises as the consequence of mutations and epigenetic alterations that activate
oncogenes and inactivate tumor suppressor genes. Through a genome-wide screen for …
oncogenes and inactivate tumor suppressor genes. Through a genome-wide screen for …
Radiotherapy and immunotherapy converge on elimination of tumor-promoting erythroid progenitor cells through adaptive immunity
Tumor-induced CD45− Ter119+ CD71+ erythroid progenitor cells, termed “Ter cells,”
promote tumor progression by secreting artemin (ARTN), a neurotrophic peptide that …
promote tumor progression by secreting artemin (ARTN), a neurotrophic peptide that …
The role of glial cell line‐derived neurotrophic factor family member artemin in neurological disorders and cancers
S Zhu, Y Li, S Bennett, J Chen, IZ Weng… - Cell …, 2020 - Wiley Online Library
Artemin (ARTN) is a member of the glial cell line‐derived neurotrophic factor (GDNF) family
ligands (GFLs), which encompasses family members, GDNF, neurturin (NRTN) and …
ligands (GFLs), which encompasses family members, GDNF, neurturin (NRTN) and …
Artemin regulates CXCR4 expression to induce migration and invasion in pancreatic cancer cells through activation of NF-κB signaling
J Wang, H Wang, J Cai, S Du, B Xin, W Wei… - Experimental cell …, 2018 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal human malignant tumor
because of the early onset of local invasion and distant metastasis. Perineural invasion is a …
because of the early onset of local invasion and distant metastasis. Perineural invasion is a …
Prognostic significance of the expression of GFRα1, GFRα3 and syndecan-3, proteins binding ARTEMIN, in mammary carcinoma
Background Artemin (ARTN) has been implicated in promoting oncogenicity, tumor growth
and invasiveness in diverse human malignancies. However, the clinical and prognostic …
and invasiveness in diverse human malignancies. However, the clinical and prognostic …
[HTML][HTML] Identification of key genes in cutaneous squamous cell carcinoma: A transcriptome sequencing and bioinformatics profiling study
DD Zou, D Xu, YY Deng, WJ Wu, J Zhang… - Annals of …, 2021 - ncbi.nlm.nih.gov
Background Long-term exposure to ultraviolet (UV) radiation can cause cutaneous
squamous cell carcinoma (cSCC), which is one of the most common malignant cancers …
squamous cell carcinoma (cSCC), which is one of the most common malignant cancers …
Multiple receptor tyrosine kinases promote the in vitro phenotype of metastatic human osteosarcoma cell lines
AN Rettew, ED Young, DC Lev, ES Kleinerman… - Oncogenesis, 2012 - nature.com
The survival rate for osteosarcoma patients with localized disease is 70% and only 25% for
patients with metastases. Therefore, novel therapeutic and prognostic tools are needed. In …
patients with metastases. Therefore, novel therapeutic and prognostic tools are needed. In …