Integrating multi-omics to unravel host-microbiome interactions in inflammatory bowel disease

Y Zhang, JP Thomas, T Korcsmaros, L Gul - Cell Reports Medicine, 2024 - cell.com
The gut microbiome is crucial for nutrient metabolism, immune regulation, and intestinal
homeostasis with changes in its composition linked to complex diseases like inflammatory …

Progress on network modeling and analysis of gut microecology: a review

M Luo, J Zhu, J Jia, H Zhang, J Zhao - Applied and Environmental …, 2024 - Am Soc Microbiol
The gut microecological network is a complex microbial community within the human body
that plays a key role in linking dietary nutrition and host physiology. To understand the …

Coupling metabolomics and exome sequencing reveals graded effects of rare damaging heterozygous variants on gene function and human traits

N Scherer, D Fässler, O Borisov, Y Cheng… - Nature Genetics, 2025 - nature.com
Genetic studies of the metabolome can uncover enzymatic and transport processes shaping
human metabolism. Using rare variant aggregation testing based on whole-exome …

In silico metabolic modelling links microbiome-derived metabolites to risk factors of Alzheimer's disease

T Hensen, S Ahmad, G Kastenmüller, R Kraaij… - Gut Microbes …, 2024 - Taylor & Francis
The gut microbiome has become increasingly recognized for its role in the pathogenesis of
Alzheimer's disease (AD) and is thought to influence AD pathogenesis via metabolic …

Bayesian Mendelian Randomization Analysis for Latent Exposures Leveraging GWAS Summary Statistics for Traits Co-Regulated by the Exposures

Y Yu, A Lakkis, B Zhao, J Jin - medRxiv, 2024 - medrxiv.org
Mendelian Randomization analysis is a popular method to infer causal relationships
between exposures and outcomes, utilizing data from genome-wide association studies …

Rumen microbiome nutriomics: Harnessing omics technologies for enhanced understanding of rumen microbiome functions and ruminant nutrition

Z Yu, M Yan, J Wang - Animal Nutriomics, 2024 - cambridge.org
The rumen microbiome has attracted tremendous interest among microbiologists and
ruminant nutritionists because of its crucial role in mediating feed digestion and fermentation …