Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Parkinson's Disease (PD) is a common and progressive neurodegenerative disorder
characterised by motor impairments as well as non-motor symptoms. While dopamine …

Abstract α-Synuclein (α-Syn) aggregation and amyloid formation is directly linked with
Parkinson's disease pathogenesis. However, the early events involved in this process …

Heavy metal exist naturally in environment, but due to human and some natural activities
they have been entered to water bodies, air and soil and have become one of the major …

Background Iron is essential for many types of biological processes. However, excessive
iron can be cytotoxic and can lead to many diseases. Since ferroptosis, which is an iron …

Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

This review article provides an overview of the different species that α‐synuclein aggregates
can populate. It also attempts to reconcile conflicting views regarding the cytotoxic roles of …

Parkinson's disease (PD) is a complex illness characterized by progressive dopaminergic
neuronal loss. Several mechanisms associated with the iron-induced death of dopaminergic …

In the CNS, iron in several proteins is involved in many important processes such as oxygen
transportation, oxidative phosphorylation, myelin production, and the synthesis and …

We hypothesize that Parkinson's disease (PD) pathogenesis can be divided into three
temporal phases. During the first phase,'triggers', such as viral infections or environmental …