Many researchers around the world are working on the development of novel anticancer
drugs with different mechanisms of action. In this case, coumarin is a highly promising …

Cancer is the second leading cause of death worldwide, and it results in around 9 million
deaths annually. The anticancer agents play an intriguing role in the treatment of cancers …

Natural coumarins and their derivatives isolated from various plants or microorganisms have
inherent antioxidant, antibacterial, antifungal, antiviral and anticancer properties among …

The cancer cases are increasing in fast pace; most of them are resulted from exposure to
harmful pollutants. Genetic factors are responsible for cancer only to a small extent …

As a class of microtubule targeting agents, colchicine binding site inhibitors (CBSIs) are
considered as promising drug candidates for cancer therapy. However, due to adverse …

Our previous study found that 2-phenyl-4-quinolone (2-PQ) derivatives are antimitotic
agents, and we adopted the drug design concept of scaffold hopping to replace the 2 …

A new set of 4-phenylcoumarin derivatives was designed and synthesized aiming to
introduce new tubulin polymerization inhibitors as anti-breast cancer candidates. All the …

This review highlights the use of functionalized organo-Li,-Mg and-Zn reagents for the
construction and selective functionalization of 5-and 6-membered fused bicyclic …

The synthesis of a unique type of π-expanded coumarin derivatives, bearing six fused
phenyl rings, was achieved via one-pot Suzuki reaction and visible light-driven …

Cancer is the main cause of death, and the emergence of resistance by cancer cells towards
existing anticancer agents is one of the major problems for effective chemotherapy, creating …