The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

Patients with primary mitochondrial oxidative phosphorylation (OxPhos) defects present with
fatigue and multi-system disorders, are often lean, and die prematurely, but the mechanistic …

Symmetric cell division requires the even partitioning of genetic information and cytoplasmic
contents between daughter cells. Whereas the mechanisms coordinating the segregation of …

There is growing scientific interest to develop scalable biological measures that capture
mitochondrial (dys) function. Mitochondria have their own genome, the mitochondrial DNA …

Genetic and biochemical defects of mitochondrial function are a major cause of human
disease, but their link to mitochondrial morphology in situ has not been defined. Here, we …

How mitochondrial DNA mutations clonally expand in an individual cell is a question that
has perplexed mitochondrial biologists for decades. A growing body of literature indicates …

Sociality has profound evolutionary roots and is observed from unicellular organisms to
multicellular animals. In line with the view that social principles apply across levels of …

Cell-to-cell heterogeneity drives a range of (patho) physiologically important phenomena,
such as cell fate and chemotherapeutic resistance. The role of metabolism, and particularly …

Mitochondrial dysfunction has been suggested to contribute to Parkinson's disease
pathogenesis, though an understanding of the extent or exact mechanism of this contribution …