Pancreatic α-cells are the major source of glucagon, a hormone that counteracts the
hypoglycemic action of insulin and strongly contributes to the correction of acute …

β-Cell replacement by in situ reprogramming of non-β-cells is a promising diabetes therapy.
Following the observation that near-total β-cell ablation in adult mice triggers the …

The mechanisms that specify and stabilize cell subtypes remain poorly understood. Here,
we identify two major subtypes of pancreatic β cells based on histone mark heterogeneity (β …

Human pancreatic plasticity is implied from multiple single-cell RNA sequencing (scRNA-
seq) studies. However, these have been invariably based on static datasets from which fate …

Ghrelin exerts key effects on islet hormone secretion to regulate blood glucose levels. Here,
we sought to determine whether ghrelin's effects on islets extend to the alteration of islet size …

The two main types of diabetes mellitus have distinct etiologies, yet a similar outcome: loss
of islet β-cell function that is solely responsible for the secretion of the insulin hormone to …

Type 2 diabetes (T2D) is characterized by chronic hyperglycemia secondary to the decline
of functional beta-cells and is usually accompanied by a reduced sensitivity to insulin …

Abstract Glucagon-like peptide-1 (GLP-1) is an incretin hormone that potentiates glucose-
stimulated insulin secretion. GLP-1 is classically produced by gut L cells; however, under …

The development of pancreatic islet endocrine cells is a tightly regulated process leading to
the generation of distinct cell types harbouring different hormones in response to small …

The mechanisms that restrict regeneration and maintain cell identity following injury are
poorly characterized in higher vertebrates. Following β-cell loss, 1–2% of the glucagon …