Cannabinoids: therapeutic use in clinical practice

C Pagano, G Navarra, L Coppola, G Avilia… - International journal of …, 2022 - mdpi.com
Medical case reports suggest that cannabinoids extracted from Cannabis sativa have
therapeutic effects; however, the therapeutic employment is limited due to the psychotropic …

Cannabinoids and the expanded endocannabinoid system in neurological disorders

L Cristino, T Bisogno, V Di Marzo - Nature Reviews Neurology, 2020 - nature.com
Anecdotal evidence that cannabis preparations have medical benefits together with the
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …

An inflammation-centric view of neurological disease: beyond the neuron

SD Skaper, L Facci, M Zusso, P Giusti - Frontiers in cellular …, 2018 - frontiersin.org
Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …

Palmitoylethanolamide in the treatment of chronic pain: a systematic review and meta-analysis of double-blind randomized controlled trials

K Lang-Illievich, C Klivinyi, C Lasser, CTA Brenna… - Nutrients, 2023 - mdpi.com
Chronic pain is a major source of morbidity for which there are limited effective treatments.
Palmitoylethanolamide (PEA), a naturally occurring fatty acid amide, has demonstrated utility …

Neuroprotective and immunomodulatory action of the endocannabinoid system under neuroinflammation

LA Kasatkina, S Rittchen, EM Sturm - International Journal of Molecular …, 2021 - mdpi.com
Endocannabinoids (eCBs) are lipid-based retrograde messengers with a relatively short half-
life that are produced endogenously and, upon binding to the primary cannabinoid receptors …

Cannabinoids in neuroinflammatory disorders: Focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases

B Abd‐Nikfarjam, A Dolati‐Somarin… - …, 2023 - Wiley Online Library
The medicinal properties of cannabis and cannabinoid‐derivative are entirely investigated
and known. In addition, the identification of psychotropic plant cannabinoids has led to more …

An update of palmitoylethanolamide and luteolin effects in preclinical and clinical studies of neuroinflammatory events

M Cordaro, S Cuzzocrea, R Crupi - Antioxidants, 2020 - mdpi.com
The inflammation process represents of a dynamic series of phenomena that manifest
themselves with an intense vascular reaction. Neuroinflammation is a reply from the central …

N-Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition

D Piomelli, L Scalvini, Y Fotio, A Lodola… - Journal of Medicinal …, 2020 - ACS Publications
N-Acylethanolamine acid amidase (NAAA) is an N-terminal cysteine hydrolase primarily
found in the endosomal–lysosomal compartment of innate and adaptive immune cells …

Dietary interventions for multiple sclerosis‐related outcomes

NE Parks, CS Jackson-Tarlton… - Cochrane Database …, 2020 - cochranelibrary.com
Background Multiple sclerosis (MS) is a common demyelinating disease of the central
nervous system. Although the exact pathogenesis remains unknown, the leading theory is …

Palmitoylethanolamide: A nutritional approach to keep neuroinflammation within physiological boundaries—A systematic review

S Petrosino, A Schiano Moriello - International Journal of Molecular …, 2020 - mdpi.com
Neuroinflammation is a physiological response aimed at maintaining the homodynamic
balance and providing the body with the fundamental resource of adaptation to endogenous …