Abstract Glutathione peroxidase 1 (GPx1) is an important cellular antioxidant enzyme that is
found in the cytoplasm and mitochondria of mammalian cells. Like most selenoenzymes, it …

Twenty of the last one hundred years of vitamin D research have involved investigations of
the brain as a target organ for this hormone. Our group was one of the first to investigate …

Abstract Nrf2 (nuclear factor erythroid 2-related factor 2) is a stress-responsive transcription
factor, associated with cellular homeostasis. Under normal conditions Nrf2 is kept in the …

The roles of both neuroinflammation and oxidative stress in the pathophysiology of epilepsy
have begun to receive considerable attention in recent years. However, these concepts are …

Ferroptosis and iron-related redox imbalance aggravate traumatic brain injury (TBI)
outcomes. NRF2 is the predominant transcription factor regulating oxidative stress and …

The global increase in lifespan noted not only in developed nations, but also in large
developing countries parallels an observed increase in a significant number of non …

Simple Summary Traumatic brain injury (TBI) is a catastrophic event to the health and life of
its sufferers, and it also affects their relatives. In addition to the underlying complications of …

TBI has been one of the top causes of death and morbidity worldwide, yet despite enormous
efforts to discover neuroprotective therapeutics for this serious disease, no beneficial …

Significance: The transcription factor NRF2 (NF-E2-related factor 2) plays an important role
as a master regulator of the cellular defense system by activating transcriptional programs of …

Inflammation is a primary component of the central nervous system injury response.
Traumatic brain and spinal cord injury are characterized by a pronounced microglial …