Neuroinflammation is an inflammatory response in the brain and spinal cord, which can
involve the activation of microglia and astrocytes. It is a common feature of many central …

The 18 kDa translocator protein (TSPO) is a highly conserved protein located in the outer
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …

Abstract Translocator Protein 18 kDa (TSPO), previously named Peripheral Benzodiazepine
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …

Reactive oxygen species (ROS), such as the superoxide anion or hydrogen peroxide, have
been established over decades of research as, on the one hand, important and versatile …

Cellular organelles are not static but show dynamism—a property that is likely relevant for
their function. In addition, they interact with other organelles in a highly dynamic manner. In …

Summary Transglutaminase type 2 (TG2) is a multifunctional enzyme that plays a key role in
mitochondria homeostasis under stressful cellular conditions. TG2 interactome analysis …

Apoptosis is a process of programmed cell death in which a cell commits suicide while
maintaining the integrity and architecture of the tissue as a whole. Apoptosis involves …

Mitochondria drive cellular adaptation to stress by retro-communicating with the nucleus.
This process is known as mitochondrial retrograde response (MRR) and is induced by …

Endothelial cells (ECs) angiogenesis is the process of sprouting new vessels from the
existing ones, playing critical roles in physiological and pathological processes such as …

The translocator protein (TSPO), located at the outer mitochondrial membrane (OMM),
serves multiple functions and contributes to numerous processes, including cholesterol …