Diagnostic liquid biopsy biomarkers in renal cell cancer

RC Zieren, PJ Zondervan, KJ Pienta, A Bex… - Nature Reviews …, 2024 - nature.com
The clinical presentation of renal cell cancer (RCC) is shifting towards incidental and early
detection, creating new challenges in RCC diagnosis. Overtreatment might be reduced with …

Extracellular vesicles: illuminating renal pathophysiology and therapeutic frontiers

L Shi, H Zeng, Z An, W Chen, Y Shan, C Ji… - European Journal of …, 2024 - Elsevier
Extracellular vesicles (EVs) are minute sacs released by cells into the extracellular milieu,
harboring an array of biomolecules including proteins, nucleic acids, and lipids. Notably, a …

Circulating exosomal mRNA signatures for the early diagnosis of clear cell renal cell carcinoma

X He, F Tian, F Guo, F Zhang, H Zhang, J Ji, L Zhao… - BMC medicine, 2022 - Springer
Background There are no proven tumor biomarkers for the early diagnosis of clear cell renal
cell carcinoma (ccRCC) thus far. This study aimed to identify novel biomarkers of ccRCC …

Lipid metabolism-related gene expression in the immune microenvironment predicts prognostic outcomes in renal cell carcinoma

Q Zhang, B Lin, H Chen, Y Ye, Y Huang… - Frontiers in …, 2023 - frontiersin.org
Background Rates of renal cell carcinoma (RCC) occurrence and mortality are steadily
rising. In an effort to address this issue, the present bioinformatics study was developed with …

Tumour tissue‐derived small extracellular vesicles reflect molecular subtypes of bladder cancer

L Dong, M Feng, MD Kuczler, K Horie… - Journal of …, 2024 - Wiley Online Library
Abstract mRNA‐based molecular subtypes have implications for bladder cancer prognosis
and clinical benefit from certain therapies. Whether small extracellular vesicles (sEVs) can …

Exploring oncogenes for renal clear cell carcinoma based on G protein-coupled receptor-associated genes

C Zhu, Z Sun, J Wang, X Meng, Z Ma, R Guo, J Niu… - Discover Oncology, 2023 - Springer
G protein-coupled receptors (GPCRs) are a class of receptors on cell membranes that
regulate various biological processes in cells, such as cell proliferation, differentiation …

Kidney Cancer and Potential Use of Urinary Extracellular Vesicles

LNH Le, J Munir, EB Kim, S Ryu - Oncology Reviews, 2024 - frontiersin.org
Kidney cancer is the 14th most common cancer globally. The 5-year relative survival rate of
kidney cancer at a localized stage is 92.9% and it declines to 17.4% in metastatic stage …

Unraveling the Impact of Extracellular Vesicle-Depleted Serum on Endothelial Cell Characteristics over Time

LFC Garcia, PF Wowk, L Albrecht - International Journal of Molecular …, 2024 - mdpi.com
Extracellular vesicles (EVs) are produced by all kinds of cells, including endothelial cells. It
has been observed that EVs present in fetal bovine serum (FBS), broadly used in cell …

Comprehensive analysis of transcriptome characteristics and identification of TLK2 as a potential biomarker in dermatofibrosarcoma protuberans

X Zhang, D Sun, H Zheng, Y Rao, Y Deng… - Frontiers in …, 2022 - frontiersin.org
Background: Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous sarcoma
characterized by local invasion and recurrence. RNA sequencing (RNA-seq) allows the …

[HTML][HTML] Exosomal mRNA Cargo are biomarkers of tumor and immune cell populations in pediatric osteosarcoma

JLK Ong, NFF Jalaludin, MK Wong, SH Tan… - Translational …, 2024 - Elsevier
Osteosarcoma is the commonest malignant bone tumor of children and adolescents and is
characterized by a high risk of recurrence despite multimodal therapy, especially in …