Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
E Connell, G Le Gall, MG Pontifex, S Sami… - Molecular …, 2022 - Springer
A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …
of worldwide age-related cognitive decline and dementia. In the absence of effective …
Defeating Alzheimer's disease and other dementias: a priority for European science and society
Executive summary Alzheimer's disease (AD) is the leading cause of dementia, and
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …
Biomarkers used in Alzheimer's disease diagnosis, treatment, and prevention
YAR Mahaman, KS Embaye, F Huang, L Li, F Zhu… - Ageing research …, 2022 - Elsevier
Abstract Alzheimer's disease (AD), being the number one in terms of dementia burden, is an
insidious age-related neurodegenerative disease and is presently considered a global …
insidious age-related neurodegenerative disease and is presently considered a global …
Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study
VR Varma, AM Oommen, S Varma, R Casanova… - PLoS …, 2018 - journals.plos.org
Background The metabolic basis of Alzheimer disease (AD) is poorly understood, and the
relationships between systemic abnormalities in metabolism and AD pathogenesis are …
relationships between systemic abnormalities in metabolism and AD pathogenesis are …
[HTML][HTML] Body mass index and risk of dementia: analysis of individual-level data from 1.3 million individuals
M Kivimäki, R Luukkonen, GD Batty, JE Ferrie… - Alzheimer's & …, 2018 - Elsevier
Introduction Higher midlife body mass index (BMI) is suggested to increase the risk of
dementia, but weight loss during the preclinical dementia phase may mask such effects …
dementia, but weight loss during the preclinical dementia phase may mask such effects …
Omics sciences for systems biology in Alzheimer's disease: State-of-the-art of the evidence
Alzheimer's disease (AD) is characterized by non-linear, genetic-driven pathophysiological
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …
Serum neurofilament light in familial Alzheimer disease: a marker of early neurodegeneration
Objectives: To investigate whether serum neurofilament light (NfL) concentration is
increased in familial Alzheimer disease (FAD), both pre and post symptom onset, and …
increased in familial Alzheimer disease (FAD), both pre and post symptom onset, and …
Metabolic network failures in Alzheimer's disease: A biochemical road map
Abstract Introduction The Alzheimer's Disease Research Summits of 2012 and 2015
incorporated experts from academia, industry, and nonprofit organizations to develop new …
incorporated experts from academia, industry, and nonprofit organizations to develop new …
Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the …
P Lewczuk, P Riederer, SE O'bryant… - The world journal of …, 2018 - Taylor & Francis
In the 12 years since the publication of the first Consensus Paper of the WFSBP on
biomarkers of neurodegenerative dementias, enormous advancement has taken place in …
biomarkers of neurodegenerative dementias, enormous advancement has taken place in …
Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer's disease
Abstract Changes to lipid metabolism are tightly associated with the onset and pathology of
Alzheimer's disease (AD). Lipids are complex molecules comprising many isomeric and …
Alzheimer's disease (AD). Lipids are complex molecules comprising many isomeric and …