The hitchhiker's guide to the voltage-gated sodium channel galaxy
Eukaryotic voltage-gated sodium (Nav) channels contribute to the rising phase of action
potentials and served as an early muse for biophysicists laying the foundation for our current …
potentials and served as an early muse for biophysicists laying the foundation for our current …
Cardiac ion channels
▪ Abstract The normal electrophysiologic behavior of the heart is determined by ordered
propagation of excitatory stimuli that result in rapid depolarization and slow repolarization …
propagation of excitatory stimuli that result in rapid depolarization and slow repolarization …
Structure of the voltage-gated calcium channel Cav1.1 complex
INTRODUCTION Voltage-gated Ca2+ (Cav) channels activate in response to membrane
potential changes and initiate Ca2+-mediated cellular signaling cascades. The L-type, high …
potential changes and initiate Ca2+-mediated cellular signaling cascades. The L-type, high …
Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel α subunit in voltage-dependent gating and drug block
V Yarov-Yarovoy, JC McPhee, D Idsvoog… - Journal of Biological …, 2002 - ASBMB
Alanine-scanning mutagenesis of transmembrane segments IS6 and IIS6 of the rat brain Na
v 1.2 channel α subunit identified mutations N418A in IS6 and L975A in IIS6 as causing …
v 1.2 channel α subunit identified mutations N418A in IS6 and L975A in IIS6 as causing …
Crystal structure of a potassium ion transporter, TrkH
Abstract The TrkH/TrkG/KtrB proteins mediate K+ uptake in bacteria and probably evolved
from simple K+ channels by multiple gene duplications or fusions. Here we present the …
from simple K+ channels by multiple gene duplications or fusions. Here we present the …
Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia …
K Peng, Q Shu, Z Liu, S Liang - Journal of Biological Chemistry, 2002 - ASBMB
We have isolated a highly potent neurotoxin from the venom of the Chinese bird spider,
Selenocosmia huwena. This 4.1-kDa toxin, which has been named huwentoxin-IV, contains …
Selenocosmia huwena. This 4.1-kDa toxin, which has been named huwentoxin-IV, contains …
The tetrodotoxin binding site is within the outer vestibule of the sodium channel
HA Fozzard, GM Lipkind - Marine drugs, 2010 - mdpi.com
Tetrodotoxin and saxitoxin are small, compact asymmetrical marine toxins that block voltage-
gated Na channels with high affinity and specificity. They enter the channel pore's outer …
gated Na channels with high affinity and specificity. They enter the channel pore's outer …
Paralytic toxin producing dinoflagellates in Latin America: Ecology and physiology
CJ Band-Schmidt, LM Duran-Riveroll… - Frontiers in Marine …, 2019 - frontiersin.org
In this review we summarize the current state of knowledge regarding taxonomy, bloom
dynamics, toxicity, autoecology, and trophic interactions, of saxitoxin producing …
dynamics, toxicity, autoecology, and trophic interactions, of saxitoxin producing …
Structure/function characterization of μ-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels
MM Zhang, BR Green, P Catlin, B Fiedler… - Journal of Biological …, 2007 - ASBMB
Peptide neurotoxins from cone snails continue to supply compounds with therapeutic
potential. Although several analgesic conotoxins have already reached human clinical trials …
potential. Although several analgesic conotoxins have already reached human clinical trials …
Nav1. 7-A1632G mutation from a family with inherited erythromelalgia: enhanced firing of dorsal root ganglia neurons evoked by thermal stimuli
Voltage-gated sodium channel Nav1. 7 is a central player in human pain. Mutations in Nav1.
7 produce several pain syndromes, including inherited erythromelalgia (IEM), a disorder in …
7 produce several pain syndromes, including inherited erythromelalgia (IEM), a disorder in …