Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain
MP Kelly - Cellular signalling, 2018 - Elsevier
Deficits in brain function that are associated with aging and age-related diseases benefit
very little from currently available therapies, suggesting a better understanding of the …
very little from currently available therapies, suggesting a better understanding of the …
Mitochondrial proteins containing coiled-coil-helix-coiled-coil-helix (CHCH) domains in health and disease
N Modjtahedi, K Tokatlidis, P Dessen… - Trends in Biochemical …, 2016 - cell.com
Members of the coiled-coil-helix-coiled-coil-helix (CHCH) domain-containing protein family
that carry (CX 9 C) type motifs are imported into the mitochondrion with the help of the …
that carry (CX 9 C) type motifs are imported into the mitochondrion with the help of the …
CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study
M Funayama, K Ohe, T Amo, N Furuya… - The Lancet …, 2015 - thelancet.com
Background Identification of causative genes in mendelian forms of Parkinson's disease is
valuable for understanding the cause of the disease. We did genetic studies in a Japanese …
valuable for understanding the cause of the disease. We did genetic studies in a Japanese …
Reversal of phenotypic abnormalities by CRISPR/Cas9-mediated gene correction in Huntington disease patient-derived induced pluripotent stem cells
X Xu, Y Tay, B Sim, SI Yoon, Y Huang, J Ooi, KH Utami… - Stem cell reports, 2017 - cell.com
Huntington disease (HD) is a dominant neurodegenerative disorder caused by a CAG
repeat expansion in HTT. Here we report correction of HD human induced pluripotent stem …
repeat expansion in HTT. Here we report correction of HD human induced pluripotent stem …
Personalized immunotherapy against several neuronal and brain tumors
S Kuttruff-coqui, T Weinschenk, J Fritsche… - US Patent …, 2021 - Google Patents
2014-11-12 Assigned to IMMATICS BIOTECHNOLOGIES GMBH reassignment IMMATICS
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
Propagation of α-synuclein strains within human reconstructed neuronal network
S Gribaudo, P Tixador, L Bousset, A Fenyi, P Lino… - Stem Cell Reports, 2019 - cell.com
Reappraisal of neuropathological studies suggests that pathological hallmarks of
Alzheimer's disease and Parkinson's disease (PD) spread progressively along predictable …
Alzheimer's disease and Parkinson's disease (PD) spread progressively along predictable …
A 3D printed microfluidic device for production of functionalized hydrogel microcapsules for culture and differentiation of human Neuronal Stem Cells (hNSC)
K Alessandri, M Feyeux, B Gurchenkov, C Delgado… - Lab on a Chip, 2016 - pubs.rsc.org
We present here a microfluidic device that generates sub-millimetric hollow hydrogel
spheres, encapsulating cells and coated internally with a layer of reconstituted extracellular …
spheres, encapsulating cells and coated internally with a layer of reconstituted extracellular …
Unbiased profiling of isogenic Huntington disease hPSC-derived CNS and peripheral cells reveals strong cell-type specificity of CAG length effects
J Ooi, SR Langley, X Xu, KH Utami, B Sim, Y Huang… - Cell Reports, 2019 - cell.com
In Huntington disease (HD), the analysis of tissue-specific CAG repeat length effects has
been challenging, given the difficulty in obtaining relevant patient tissues with a broad range …
been challenging, given the difficulty in obtaining relevant patient tissues with a broad range …
Huntington disease as a neurodevelopmental disorder and early signs of the disease in stem cells
K Wiatr, WJ Szlachcic, M Trzeciak, M Figlerowicz… - Molecular …, 2018 - Springer
Huntington disease (HD) is a dominantly inherited disorder caused by a CAG expansion
mutation in the huntingtin (HTT) gene, which results in the HTT protein that contains an …
mutation in the huntingtin (HTT) gene, which results in the HTT protein that contains an …
Common factors in neurodegeneration: a meta-study revealing shared patterns on a multi-omics scale
Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) are heterogeneous …
Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) are heterogeneous …