Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies

S Xu, I Ilyas, PJ Little, H Li, D Kamato, X Zheng… - Pharmacological …, 2021 - Elsevier
The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …

Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy

S Shi, Y Chen, Z Luo, G Nie, Y Dai - Cell Communication and Signaling, 2023 - Springer
Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, used alone or
in combination in a variety of cancers, while it has been found to cause serious cardiac side …

Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseases

S Kakavandi, I Zare, M VaezJalali, M Dadashi… - Cell Communication and …, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is caused by a new member of the
Coronaviridae family known as severe acute respiratory syndrome coronavirus 2 (SARS …

Modulation of the innate immune response by targeting toll-like receptors: a perspective on their agonists and antagonists

S Federico, L Pozzetti, A Papa, G Carullo… - Journal of Medicinal …, 2020 - ACS Publications
Toll-like receptors (TLRs) are a class of proteins that recognize pathogen-associated
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …

Endothelial dysfunction: molecular mechanisms and clinical implications

X Wang, B He - MedComm, 2024 - Wiley Online Library
Cardiovascular disease (CVD) and its complications are a leading cause of death
worldwide. Endothelial dysfunction plays a crucial role in the initiation and progression of …

Greenspace, inflammation, cardiovascular health, and cancer: a review and conceptual framework for greenspace in cardio-oncology research

JC Bikomeye, AM Beyer, JL Kwarteng… - International Journal of …, 2022 - mdpi.com
Cardiovascular disease (CVD) is a leading cause of global morbidity and mortality. Cancer
survivors have significantly elevated risk of poor cardiovascular (CV) health outcomes due to …

Toll-like receptor 7 regulates cardiovascular diseases

M Shafeghat, S Kazemian, A Aminorroaya… - International …, 2022 - Elsevier
Cardiovascular disease (CVD) is the major leading cause of morbidity and mortality
worldwide. According to the pro-inflammatory nature of CVD, recent studies highlighted the …

Ginger: A complementary approach for management of cardiovascular diseases

NM Roudsari, NA Lashgari, S Momtaz… - Biofactors, 2021 - Wiley Online Library
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide.
Inflammation and oxidative stress play critical roles in progression of various types of CVD …

Mechanistic insight: linking cardiovascular complications of inflammatory bowel disease

H Kumarapperuma, R Wang, PJ Little… - Trends in Cardiovascular …, 2024 - Elsevier
Cardiovascular diseases (CVD) are the leading cause of mortality worldwide despite an
aggressive reduction of traditional cardiovascular risk factors. Underlying inflammatory …

Bergapten alleviates depression-like behavior by inhibiting cyclooxygenase 2 activity and NF-κB/MAPK signaling pathway in microglia

M Yan, X Bo, J Zhang, S Liu, X Li, Y Liao, Q Liu… - Experimental …, 2023 - Elsevier
Major depressive disorder (MDD) is a common psychiatric disorder that severely affects
human life and health. However, the pathological mechanism of MDD is unclear, and …