[HTML][HTML] Hypoxia induced exosomal circRNA promotes metastasis of Colorectal Cancer via targeting GEF-H1/RhoA axis
H Yang, H Zhang, Y Yang, X Wang, T Deng, R Liu… - Theranostics, 2020 - ncbi.nlm.nih.gov
Hypoxia is one of the important properties of solid tumor. However, oxygen supply within
tumors is generally heterogeneous according to the distance from the nearest blood vessel …
tumors is generally heterogeneous according to the distance from the nearest blood vessel …
Rho GTPases and cancer
H Li, K Peyrollier, G Kilic, C Brakebusch - Biofactors, 2014 - Wiley Online Library
Rho GTPases are a family of small GTPases, which play an important role in the regulation
of the actin cytoskeleton. Not surprisingly, Rho GTPases are crucial for cell migration and …
of the actin cytoskeleton. Not surprisingly, Rho GTPases are crucial for cell migration and …
Pumping the brakes on RAS–negative regulators and death effectors of RAS
DR Harrell Stewart, GJ Clark - Journal of cell science, 2020 - journals.biologists.com
Mutations that activate the RAS oncoproteins are common in cancer. However, aberrant
upregulation of RAS activity often occurs in the absence of activating mutations in the RAS …
upregulation of RAS activity often occurs in the absence of activating mutations in the RAS …
Microtubules regulate GEF-H1 in response to extracellular matrix stiffness
JN Heck, SM Ponik, MG Garcia-Mendoza… - Molecular biology of …, 2012 - Am Soc Cell Biol
Breast epithelial cells sense the stiffness of the extracellular matrix through Rho-mediated
contractility. In turn, matrix stiffness regulates RhoA activity. However, the upstream signaling …
contractility. In turn, matrix stiffness regulates RhoA activity. However, the upstream signaling …
Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule-and Src-mediated pathways
Rho family GTPases are activated with precise spatiotemporal control by guanine nucleotide
exchange factors (GEFs). Guanine exchange factor H1 (GEF-H1), a RhoA activator, is …
exchange factors (GEFs). Guanine exchange factor H1 (GEF-H1), a RhoA activator, is …
The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1
J Cullis, D Meiri, MJ Sandi, N Radulovich, OA Kent… - Cancer cell, 2014 - cell.com
Cellular transformation by oncogenic RAS engages the MAPK pathway under strict
regulation by the scaffold protein KSR-1. Here, we report that the guanine nucleotide …
regulation by the scaffold protein KSR-1. Here, we report that the guanine nucleotide …
[HTML][HTML] The PTTG1-targeting miRNAs miR-329, miR-300, miR-381, and miR-655 inhibit pituitary tumor cell tumorigenesis and are involved in a p53/PTTG1 regulation …
H Liang, R Wang, C Diao, J Li, J Su, S Zhang - Oncotarget, 2015 - ncbi.nlm.nih.gov
Deregulation of the pituitary tumor transforming gene (PTTG1), a newly discovered
oncogene, is a hallmark of various malignancies, including pituitary tumors. However, the …
oncogene, is a hallmark of various malignancies, including pituitary tumors. However, the …
Dual-specificity phosphatase 6 deficiency regulates gut microbiome and transcriptome response against diet-induced obesity in mice
The gut microbiota plays profound roles in host metabolism and the inflammatory response
associated with the development of obesity. Dusp6-deficient mice have been shown to be …
associated with the development of obesity. Dusp6-deficient mice have been shown to be …
Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion
DA Medvetz, D Khabibullin, V Hariharan… - PloS one, 2012 - journals.plos.org
Birt-Hogg-Dube (BHD) is a tumor suppressor gene syndrome associated with
fibrofolliculomas, cystic lung disease, and chromophobe renal cell carcinoma. In seeking to …
fibrofolliculomas, cystic lung disease, and chromophobe renal cell carcinoma. In seeking to …
Regulation of the RhoA exchange factor GEF-H1 by profibrotic stimuli through a positive feedback loop involving RhoA, MRTF, and Sp1
S Venugopal, Q Dan… - … of Physiology-Cell …, 2024 - journals.physiology.org
RhoA and its effectors, the transcriptional coactivators myocardin-related transcription factor
(MRTF) and serum response factor (SRF), control epithelial phenotype and are …
(MRTF) and serum response factor (SRF), control epithelial phenotype and are …