An Overview of In Vitro Assays of 64Cu-, 68Ga-, 125I-, and 99mTc-Labelled Radiopharmaceuticals Using Radiometric Counters in the Era of Radiotheranostics

V Benfante, A Stefano, M Ali, R Laudicella, W Arancio… - Diagnostics, 2023 - mdpi.com
Radionuclides are unstable isotopes that mainly emit alpha (α), beta (β) or gamma (γ)
radiation through radiation decay. Therefore, they are used in the biomedical field to label …

Unveiling the Complexities: Exploring Mechanisms of Anthracycline-Induced Cardiotoxicity

R Tayal, A Mannan, S Singh, S Dhiman… - Current Cardiology …, 2024 - benthamdirect.com
The coexistence of cancer and heart disease, both prominent causes of illness and death, is
further exacerbated by the detrimental impact of chemotherapy. Anthracycline-induced …

Targeted hollow pollen silica nanoparticles for enhanced intravesical therapy of bladder cancer

L Wang, F Qi, L Bi, J Yan, X Han, Y Wang… - Biomaterials …, 2023 - pubs.rsc.org
Bladder cancer (BC), such as non-muscle invasive bladder cancer (NMIBC), has a
significantly high recurrence rate even after intravesical therapy because traditional …

Pirarubicin loaded biodegradable nanoparticles downregulate IL-6, COX-II and TNF-α along with oxidative stress markers in comparison to conventional pirarubicin in …

N Shakir, A Sharif, S Ali, B Akhtar, MF Akhtar… - Journal of Drug Delivery …, 2023 - Elsevier
Pirarubicin (PRB) is an anthracycline antibiotic that has shown equal or superior cytotoxicity
compared to doxorubicin. However, the detailed toxicological profile for Pirarubicin has not …

Radioiodination, nasal nanoformulation and preliminary evaluation of isovanillin: a new potential brain cancer-targeting agent

OA El-Kawy, HA Shweeta, KM Attallah - Applied Radiation and Isotopes, 2022 - Elsevier
Brain cancer is a challenging disease to treat using conventional approaches. The present
investigation aimed to develop a radiopharmaceutical targeting brain cancer based on …

Preparation and evaluation of radiolabeled gliclazide parenteral nanoemulsion as a new tracer for pancreatic β-cells mass

OA El-Kawy, IT Ibrahim, HA Shewatah… - International Journal of …, 2023 - Taylor & Francis
Purpose The present investigation aims to develop and evaluate a radiopharmaceutical for
targeting and assessing β-cells mass based on gliclazide, an antidiabetic drug that …

Preparation and preliminary evaluation study of [131I]iodocolchicine-gallic-AuNPs: a potential scintigraphic agent for inflammation detection

BM Essa, AA Selim, OA El-Kawy… - International journal of …, 2022 - Taylor & Francis
Background Nanomedicine offers great potential for scintigraphic diagnostic imaging with
lower risk and higher quality compared to other traditional techniques. Objectives This work …

Investigation of a Radio-Iodinated Alpha-Mangostin for Targeting Estrogen Receptor Alpha (ERα) in Breast Cancer: In Silico Design, Synthesis, and Biological …

M Muchtaridi, W Nurhidayah, TM Fakih… - Drug Design …, 2024 - Taylor & Francis
Introduction Alpha-mangostin (AM), the most representative xanthone derivative isolated
from the rind of the Purple Mangosteen (Garcinia mangostana Linn), has been reported …

Concomitant Delivery of Pirarubicin and Salinomycin Synergistically Enhanced the Efficacy of Cancer Therapy and Reduced the Risk of Cancer Relapse

M Anees, P Gupta, H Kaur, S Kharbanda, H Singh - AAPS PharmSciTech, 2024 - Springer
Pirarubicin attracted considerable attention in clinical studies because of its high therapeutic
efficacy and reduced toxicity in comparison with other anthracyclines. Nevertheless,~ 30 …

Radiolabeled chemotherapeutics as a novel strategy for targeted cancer therapy: current insights and future perspectives

A Jain, T Das - Journal of Radioanalytical and Nuclear Chemistry, 2024 - Springer
The use of radiolabeled chemotherapeutics is an exciting prospect in the management of
cancer, as lethal cytotoxic radiation dose can be delivered to the cancerous lesions by using …