Interferon-λ orchestrates innate and adaptive mucosal immune responses
Type III interferon (IFN-λ) was initially thought to have functions similar to those of the type I
interferons (IFN-α and IFN-β). New findings have indicated, however, that IFN-λ has a non …
interferons (IFN-α and IFN-β). New findings have indicated, however, that IFN-λ has a non …
Immunity to Cryptosporidium: insights into principles of enteric responses to infection
Cryptosporidium parasites replicate within intestinal epithelial cells and are an important
cause of diarrhoeal disease in young children and in patients with primary and acquired …
cause of diarrhoeal disease in young children and in patients with primary and acquired …
[HTML][HTML] Segmented filamentous bacteria prevent and cure rotavirus infection
Rotavirus (RV) encounters intestinal epithelial cells amidst diverse microbiota, opening
possibilities of microbes influencing RV infection. Although RV clearance typically requires …
possibilities of microbes influencing RV infection. Although RV clearance typically requires …
Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses
Cryptosporidium infects gastrointestinal epithelium and is a leading cause of infectious
diarrhea and diarrheal-related death in children worldwide. There are no vaccines and no …
diarrhea and diarrheal-related death in children worldwide. There are no vaccines and no …
Type III IFNs: beyond antiviral protection
SV Kotenko, A Rivera, D Parker, JE Durbin - Seminars in immunology, 2019 - Elsevier
The unexpected discovery of a novel family of antiviral mediators, type III IFNs or IFN-λs,
challenged the widely accepted primacy of type I IFNs in antiviral immunity, and it is now …
challenged the widely accepted primacy of type I IFNs in antiviral immunity, and it is now …
Cryptosporidium infection of human small intestinal epithelial cells induces type III interferon and impairs infectivity of Rotavirus
Cryptosporidiosis is a major cause of severe diarrheal disease in infants from resource poor
settings. The majority of infections are caused by the human-specific pathogen C. hominis …
settings. The majority of infections are caused by the human-specific pathogen C. hominis …
Pathophysiology of ocular toxoplasmosis: Facts and open questions
V Greigert, F Bittich-Fahmi, AW Pfaff - PLOS Neglected Tropical …, 2020 - journals.plos.org
Infections with the protozoan parasite Toxoplasma gondii are frequent, but one of its main
consequences, ocular toxoplasmosis (OT), remains poorly understood. While its clinical …
consequences, ocular toxoplasmosis (OT), remains poorly understood. While its clinical …
[HTML][HTML] Enterocyte–innate lymphoid cell crosstalk drives early IFN-γ-mediated control of Cryptosporidium
JA Gullicksrud, A Sateriale, JB Engiles, AR Gibson… - Mucosal …, 2022 - Elsevier
The intestinal parasite, Cryptosporidium, is a major contributor to global child mortality and
causes opportunistic infection in immune deficient individuals. Innate resistance to …
causes opportunistic infection in immune deficient individuals. Innate resistance to …
Role of innate interferon responses at the ocular surface in herpes simplex virus-1-induced herpetic stromal keratitis
Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen that primarily infects
epithelial cells of the orofacial mucosa. After initial lytic replication, HSV-1 enters sensory …
epithelial cells of the orofacial mucosa. After initial lytic replication, HSV-1 enters sensory …
The enteric pathogen Cryptosporidium parvum exports proteins into the cytosol of the infected host cell
JE Dumaine, A Sateriale, AR Gibson, AG Reddy… - Elife, 2021 - elifesciences.org
The parasite Cryptosporidium is responsible for diarrheal disease in young children causing
death, malnutrition, and growth delay. Cryptosporidium invades enterocytes where it …
death, malnutrition, and growth delay. Cryptosporidium invades enterocytes where it …