Natural products, and especially the active ingredients found in traditional Chinese medicine
(TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in …

Pharmacodynamics material basis and effective mechanisms are the two main issues to
decipher the mechnisms of action of Traditional Chinese medicines (TCMs) for the treatment …

Understanding tissue macrophage biology has become challenging in recent years due the
ever-increasing complexity in macrophage-subset identification and functional …

Macrophages are essential for skeletal muscle homeostasis, but how their dysregulation
contributes to the development of fibrosis in muscle disease remains unclear. Here, we used …

Tissue‐resident cardiac macrophage subsets mediate cardiac tissue inflammation and
repair after acute myocardial infarction (AMI). CC chemokine receptor 2 (CCR2)‐expressing …

Background The term" vascular cognitive impairment"(VCI) describes various cognitive
conditions that include vascular elements. It increases the risk of morbidity and mortality in …

Osteoarthritis (OA) is the most common joint disease, affecting over 300 million people world-
wide. Accumulating evidence attests to the important roles of the immune system in OA …

The immune system plays a critical role during myocardial injury, contributing to repair and
remodeling post myocardial infarction (MI). The myocardial infarct and border zone exhibit …

Early and prompt reperfusion therapy has markedly improved the survival rates among
patients enduring myocardial infarction (MI). Nonetheless, the resulting adverse remodeling …

Rationale: The transition from acute inflammation to fibrosis following myocardial ischemia‒
reperfusion (MIR) significantly affects prognosis. Macrophages play a pivotal role in …