Immune pathomechanism and classification of drug hypersensitivity
WJ Pichler - Allergy, 2019 - Wiley Online Library
Drug hypersensitivity reactions (DHR) are based on distinct mechanisms and are clinically
heterogeneous. Taking into account that also off‐target activities of drugs may lead to …
heterogeneous. Taking into account that also off‐target activities of drugs may lead to …
SJS/TEN 2017: building multidisciplinary networks to drive science and translation
KD White, R Abe, M Ardern-Jones… - The Journal of Allergy …, 2018 - Elsevier
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a life-threatening,
immunologically mediated, and usually drug-induced disease with a high burden to …
immunologically mediated, and usually drug-induced disease with a high burden to …
The incidence, causes, and risk factors of acute kidney injury in patients receiving immune checkpoint inhibitors
Results We included 1016 patients in the analysis. Average age was 63 (SD 13) years, 61%
were men, and 91% were white. Mean baseline creatinine was 0.9 mg/dl (SD 0.4 mg/dl) …
were men, and 91% were white. Mean baseline creatinine was 0.9 mg/dl (SD 0.4 mg/dl) …
Recent developments and highlights in drug hypersensitivity
Drug hypersensitivity reactions (DHRs) are nowadays the third cause of allergy after rhinitis
and asthma with a significant increase in prevalence in both adults and paediatric …
and asthma with a significant increase in prevalence in both adults and paediatric …
[HTML][HTML] Incidence and clinical features of immune-related acute kidney injury in patients receiving programmed cell death ligand-1 inhibitors
H Seethapathy, S Zhao, IA Strohbehn, M Lee… - Kidney international …, 2020 - Elsevier
Background Programmed cell death receptor ligand 1 (PD-L1) inhibitors are immune
checkpoint inhibitors (ICIs) with a side effect profile that may differ from other classes of ICIs …
checkpoint inhibitors (ICIs) with a side effect profile that may differ from other classes of ICIs …
Immunopharmacogenomics: mechanisms of HLA‐associated drug reactions
P Deshpande, RJ Hertzman… - Clinical …, 2021 - Wiley Online Library
The human leukocyte antigen (HLA) system is the most polymorphic in the human genome
that has been associated with protection and predisposition to a broad array of infectious …
that has been associated with protection and predisposition to a broad array of infectious …
Evolving insights into the mechanisms of toxicity associated with immune checkpoint inhibitor therapy
Immune checkpoint inhibitors have emerged as a revolutionary treatment option for patients
with various types of malignancy. Although these agents afford a significant improvement in …
with various types of malignancy. Although these agents afford a significant improvement in …
Making a diagnosis in severe cutaneous drug hypersensitivity reactions
MR Ardern-Jones, M Mockenhaupt - Current Opinion in Allergy …, 2019 - journals.lww.com
Careful phenotypic analysis of the increasingly complex recognized patterns of SCAR
facilitates the enhancement in our understanding of T-cell mediated drug hypersensitivity …
facilitates the enhancement in our understanding of T-cell mediated drug hypersensitivity …
Incidence and risk factors of acute kidney injury, and its effect on mortality among Japanese patients receiving immune check point inhibitors: a single-center …
Y Shimamura, S Watanabe, T Maeda, K Abe… - Clinical and …, 2021 - Springer
Abstract Background Immune checkpoint inhibitors (ICPis) are associated with multi-organ
immune-related adverse effects. Here, we examined the incidence rate, recovery rate, and …
immune-related adverse effects. Here, we examined the incidence rate, recovery rate, and …
Identifying patients at risk of acute kidney injury among patients receiving immune checkpoint inhibitors: a machine learning approach
X Yu, R Wu, Y Ji, M Huang, Z Feng - Diagnostics, 2022 - mdpi.com
Background: The benefits of immune checkpoint inhibitors (ICPis) in the treatment of patients
with malignancies emerged recently, but immune-related adverse events (IRAEs), including …
with malignancies emerged recently, but immune-related adverse events (IRAEs), including …