Emerging mechanisms of cell competition

NE Baker - Nature Reviews Genetics, 2020 - nature.com
The growth and survival of cells within tissues can be affected by 'cell competition'between
different cell clones. This phenomenon was initially recognized between wild-type cells and …

The synaptic vesicle cycle revisited: new insights into the modes and mechanisms

NL Chanaday, MA Cousin, I Milosevic… - Journal of …, 2019 - Soc Neuroscience
Neurotransmission is sustained by endocytosis and refilling of synaptic vesicles (SVs)
locally within the presynapse. Until recently, a consensus formed that after exocytosis, SVs …

A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila

S Nagarkar-Jaiswal, PT Lee, ME Campbell, K Chen… - elife, 2015 - elifesciences.org
Here, we document a collection of∼ 7434 MiMIC (Minos Mediated Integration Cassette)
insertions of which 2854 are inserted in coding introns. They allowed us to create a library of …

MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes

KJT Venken, KL Schulze, NA Haelterman, H Pan… - Nature …, 2011 - nature.com
We demonstrate the versatility of a collection of insertions of the transposon Minos-mediated
integration cassette (MiMIC), in Drosophila melanogaster. MiMIC contains a gene-trap …

Exocytosis and endocytosis: modes, functions, and coupling mechanisms

LG Wu, E Hamid, W Shin… - Annual review of …, 2014 - annualreviews.org
Vesicle exocytosis releases content to mediate many biological events, including synaptic
transmission essential for brain functions. Following exocytosis, endocytosis is initiated to …

Synaptic vesicle endocytosis

Y Saheki, P De Camilli - Cold Spring Harbor …, 2012 - cshperspectives.cshlp.org
Neurons can sustain high rates of synaptic transmission without exhausting their supply of
synaptic vesicles. This property relies on a highly efficient local endocytic recycling of …

100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future

HJ Bellen, C Tong, H Tsuda - Nature Reviews Neuroscience, 2010 - nature.com
Discoveries in fruit flies have greatly contributed to our understanding of neuroscience. The
use of an unparalleled wealth of tools, many of which originated between 1910–1960, has …

Synaptic vesicle recycling: steps and principles

SO Rizzoli - The EMBO journal, 2014 - embopress.org
Synaptic vesicle recycling is one of the best‐studied cellular pathways. Many of the proteins
involved are known, and their interactions are becoming increasingly clear. However, as for …

Transmission, development, and plasticity of synapses

KP Harris, JT Littleton - Genetics, 2015 - academic.oup.com
Chemical synapses are sites of contact and information transfer between a neuron and its
partner cell. Each synapse is a specialized junction, where the presynaptic cell assembles …

Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and disease

M Vos, E Lauwers, P Verstreken - Frontiers in synaptic neuroscience, 2010 - frontiersin.org
Cell types rich in mitochondria, including neurons, display a high energy demand and a
need for calcium buffering. The importance of mitochondria for proper neuronal function is …