Abstract 'If G-quadruplexes form so readily in vitro, Nature will have found a way of using
them in vivo'(Statement by Aaron Klug over 30 years ago). During the last decade, four …

Eukaryotic transcription factors (TFs) from the same structural family tend to bind similar DNA
sequences, despite the ability of these TFs to execute distinct functions in vivo. The cell …

Transcription factors recognize specific genomic sequences to regulate complex gene-
expression programs. Although it is well-established that transcription factors bind to specific …

Biological molecules are often highly dynamic, and this flexibility can be critical for function.
The large range of sampled timescales and the fact that many of the conformers that are …

Rare tautomeric and anionic nucleobases are believed to have fundamental biological
roles, but their prevalence and functional importance has remained elusive because they …

DNA serves as a versatile template for few-atom silver clusters and their organized self-
assembly. These clusters possess unique structural and photophysical properties that are …

The perspective reviews quantitative investigations of chemical exchange phenomena in
proteins and other biological macromolecules using NMR spectroscopy, particularly …

It is well-established that dynamics are central to protein function; their importance is
implicitly acknowledged in the principles of the Monod, Wyman and Changeux model of …

The importance of dynamics to biomolecular function is becoming increasingly clear. A
description of the structure–function relationship must, therefore, include the role of motion …

RNA dynamics play a fundamental role in many cellular functions. However, there is no
general framework to describe these complex processes, which typically consist of many …