When healing turns into killing–the pathophysiology of pancreatic and hepatic fibrosis

PE Ferdek, D Krzysztofik, KB Stopa… - The Journal of …, 2022 - Wiley Online Library
Disorders such as pancreatic or hepatic fibrosis are a cruel reminder that disruption of the
delicate physiological balance could result in severe pathological consequences. Fibrosis is …

Animal models of primary biliary cholangitis: status and challenges

X Wang, Y Wei, Y Yang, Y Yang, H Li, Y Li, F Zhang… - Cell & Bioscience, 2023 - Springer
Background Primary biliary cholangitis (PBC) is an autoimmune liver disease. The aetiology
of PBC remains unclear, and its pathogenesis is complex. Animal models are essential to …

MCPIP1 alleviates depressive‑like behaviors in mice by inhibiting the TLR4/TRAF6/NF‑κB pathway to suppress neuroinflammation

Q An, J Xia, F Pu, S Shi - Molecular Medicine Reports, 2023 - spandidos-publications.com
Lipopolysaccharide-induced (LPS) neuroinflammation serves an important role in the
development of depression. Monocyte chemotactic protein-1-induced protein 1 (MCPIP1 …

Hepatic MCPIP1 protein levels are reduced in NAFLD patients and are predominantly expressed in cholangiocytes and liver endothelium

N Pydyn, J Kadluczka, P Major, T Hutsch… - Hepatology …, 2023 - journals.lww.com
Methods: In this study, we investigated MCPIP1 expression in the liver and peripheral blood
mononuclear cells (PBMCs) collected from a cohort of 36 control and NAFLD patients …

ZC3H12A inhibits tumor growth and metastasis of breast cancer under hypoxic condition via the inactivation of IL-17 signaling pathway

Z Luo, F Yang, K Liu, Z Ding - Cell Cycle, 2024 - Taylor & Francis
Hypoxia is a major contributor to tumor microenvironment (TME) and metastasis in most
solid tumors. We seek to screen hypoxia-related genes affecting metastasis in breast cancer …

Macrophage-specific MCPIP1/Regnase-1 attenuates kidney ischemia-reperfusion injury by shaping the local inflammatory response and tissue regeneration

A Ribeiro, E Dobosz, M Krill, P Köhler, M Wadowska… - Cells, 2022 - mdpi.com
Sterile inflammation either resolves the initial insult or leads to tissue damage. Kidney
ischemia/reperfusion injury (IRI) is associated with neutrophilic infiltration, enhanced …

[HTML][HTML] Zebrafish ppp1r21 mutant as a model for the study of primary biliary cholangitis

C Wu, W Zhang, Y Luo, C Cheng, X Wang… - Journal of Genetics and …, 2023 - Elsevier
Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disease that progresses
to fibrosis and cirrhosis, resulting from the gradual destruction of intrahepatic bile ducts …

[HTML][HTML] MCPIP1 inhibits hepatic stellate cell activation in autocrine and paracrine manners, preventing liver fibrosis

N Pydyn, A Ferenc, K Trzos, E Pospiech… - Cellular and Molecular …, 2024 - Elsevier
Background & Aims Hepatic fibrosis is characterized by enhanced deposition of extracellular
matrix (ECM), which results from the wound healing response to chronic, repeated injury of …

MCPIP1 alleviated alcohol-induced immune dysfunction via the MAPK/ERK signaling pathway

Y Shen, K Zhang, R Wang, S Sun, Y Yang, Y Yao… - …, 2022 - Springer
Rationale In recent years, monocyte chemotactic protein-induced protein 1 (MCPIP1) has
been reported to control inflammation via IL-10. Objectives The aims of this study were to …

Role of Mcpip1 in obesity‐induced hepatic steatosis as determined by myeloid and liver‐specific conditional knockouts

N Pydyn, D Żurawek, J Kozieł, E Kus… - The FEBS …, 2021 - Wiley Online Library
Monocyte chemoattractant protein‐induced protein 1 (MCPIP1, alias Regnase 1) is a
negative regulator of inflammation, acting through cleavage of transcripts coding for …