Traumatic brain injury (TBI) is a leading cause of death and disability worldwide and is a risk
factor for dementia later in life. Research into the pathophysiology of TBI has focused on the …

Synapse loss is the strongest correlate for cognitive decline in Alzheimer's disease. The
mechanisms underlying synapse loss have been extensively investigated using mouse …

Alzheimer's disease (AD) is characterized by cognitive decline and neuronal network
dysfunction, but the underlying mechanisms remain unknown. In the hippocampus …

The loss of excitatory synapses is known to underlie the cognitive deficits in Alzheimer's
disease (AD). Although much is known about the mechanisms underlying synaptic loss in …

Alzheimer's disease (AD) is a progressive neurodegenerative disease that is the most
common cause of dementia. Symptoms of AD include memory loss, disorientation, mood …

Intramembrane proteases execute fundamental biological processes ranging from crucial
signaling events to general membrane proteostasis. Despite the availability of structural …

Alzheimer's disease (AD) is associated with aberrant neuronal activity, which is believed to
critically determine disease symptoms. How these activity alterations emerge, how stable …

NOTCH plays a pivotal role during normal development and in congenital disorders and
cancer. γ-secretase inhibitors are commonly used to probe NOTCH function, but also block …

Neuronal network dysfunction is a hallmark of Alzheimer's disease (AD). However, the
underlying pathomechanisms remain unknown. We analyzed the hippocampal …

Neurodegenerative processes in Alzheimer's disease (AD) affect the structure and function
of neurons [1–4], resulting in altered neuronal activity patterns comprising neuronal hypo …