Gene–stress–epigenetic regulation of FKBP5: clinical and translational implications
Stress responses and related outcomes vary markedly across individuals. Elucidating the
molecular underpinnings of this variability is of great relevance for developing individualized …
molecular underpinnings of this variability is of great relevance for developing individualized …
Current research trends in early life stress and depression: Review of human studies on sensitive periods, gene–environment interactions, and epigenetics
Early life stress, such as childhood abuse, neglect and loss, is a well established major risk
factor for developing depressive disorders later in life. We here summarize and discuss …
factor for developing depressive disorders later in life. We here summarize and discuss …
Understanding the molecular mechanisms underpinning gene by environment interactions in psychiatric disorders: the FKBP5 model
Epidemiologic and genetic studies suggest common environmental and genetic risk factors
for a number of psychiatric disorders, including depression, bipolar disorder, and …
for a number of psychiatric disorders, including depression, bipolar disorder, and …
[HTML][HTML] A functional neuro-anatomical model of human attachment (NAMA): Insights from first-and second-person social neuroscience
Attachment theory, developed by Mary Ainsworth and John Bowlby about seventy years
ago, has become one of the most influential and comprehensive contemporary psychology …
ago, has become one of the most influential and comprehensive contemporary psychology …
Gene–environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism
Psychiatric phenotypes are multifactorial and polygenic, resulting from the complex interplay
of genes and environmental factors that act cumulatively throughout an organism's lifetime …
of genes and environmental factors that act cumulatively throughout an organism's lifetime …
HPA axis responses to psychological challenge linking stress and disease: What do we know on sources of intra-and interindividual variability?
S Zänkert, S Bellingrath, S Wüst, BM Kudielka - Psychoneuroendocrinology, 2019 - Elsevier
Stress is an ubiquitous phenomenon with significant impact on human physiology when it
lasts too long, when it is too intense, or when it hits vulnerable individuals. Examining the …
lasts too long, when it is too intense, or when it hits vulnerable individuals. Examining the …
Gene× environment vulnerability factors for PTSD: the HPA-axis
Post-traumatic stress disorder (PTSD) is a severely debilitating psychiatric condition.
Although a lifetime trauma incidence of 40–90% has been reported in the general …
Although a lifetime trauma incidence of 40–90% has been reported in the general …
The generation R study: biobank update 2015
CJ Kruithof, MN Kooijman, CM van Duijn… - European journal of …, 2014 - Springer
Abstract The Generation R Study is a population-based prospective cohort study from fetal
life until adulthood. The study is designed to identify early environmental and genetic causes …
life until adulthood. The study is designed to identify early environmental and genetic causes …
Moderation of adult depression by a polymorphism in the FKBP5 gene and childhood physical abuse in the general population
K Appel, C Schwahn, J Mahler, A Schulz… - …, 2011 - nature.com
Childhood maltreatment and depressive disorders have both been associated with a
dysregulation of the hypothalamic–pituitary–adrenal axis. The FKBP5 gene codes for a co …
dysregulation of the hypothalamic–pituitary–adrenal axis. The FKBP5 gene codes for a co …
Complex trauma
M Kliethermes, M Schacht… - Child and Adolescent …, 2014 - childpsych.theclinics.com
The construct of complex trauma has evolved significantly in the past 25 years. Part of the
challenge with the development of this concept is that the term complex trauma has been …
challenge with the development of this concept is that the term complex trauma has been …