Macromolecules drive the complex behavior of neurons. For example, channels and
transporters control the movements of ions across membranes, SNAREs direct the fusion of …

Nicotinic acetylcholine receptors (AChRs) are one of the best characterized ion channels
from the Cys-loop receptor superfamily. The study of acetylcholine binding proteins and …

Many clinically important drugs target ligand-gated ion channels; however, the mechanisms
by which these drugs modulate channel function remain elusive. Benzodiazepines (BZDs) …

Cys-loop receptors (CLR) are pentameric ligand-gated ion channels that mediate fast
excitatory or inhibitory transmission in the nervous system. Strychnine and d-tubocurarine (d …

Venom peptide toxins such as conotoxins play a critical role in the characterization of
nicotinic acetylcholine receptor (nAChR) structure and function and have potential as …

αβ T-cell receptors (TCRs) recognize multiple antigenic peptides bound and presented by
major histocompatibility complex molecules. TCR cross-reactivity has been attributed in part …

Relationship between stability and activity of enzymes is maintained by underlying
conformational flexibility. In thermophilic enzymes, a decrease in flexibility causes low …

Covalent modification of α7 W55C nicotinic acetylcholine receptors (nAChR) with the
cysteine-modifying reagent [2-(trimethylammonium) ethyl] methanethiosulfonate (MTSET+) …

Neurotransmitter receptors of the Cys-loop superfamily mediate rapid synaptic transmission
throughout the nervous system, and include receptors activated by ACh, GABA, glycine and …

Cys-loop receptors mediate rapid transmission throughout the nervous system by converting
a chemical signal into an electric one. They are pentameric proteins with an extracellular …