An optimally functional brain requires both excitatory and inhibitory inputs that are regulated
and balanced. A perturbation in the excitatory/inhibitory balance—as is the case in some …

Since its introduction 16 years ago, the astrocyte–neuron lactate shuttle (ANLS) model has
profoundly modified our understanding of neuroenergetics by bringing a cellular and …

Monocarboxylate transporters (MCTs) are proton‐linked membrane carriers involved in the
transport of monocarboxylates such as lactate, pyruvate, as well as ketone bodies. They …

Lactate is a potential energy source for the brain. The aim of this study was to establish
whether systemic lactate is a brain energy source. We measured in vivo cerebral lactate …

Astrocytic energy demand is stimulated by K+ and glutamate uptake, signaling processes,
responses to neurotransmitters, Ca2+ fluxes, and filopodial motility. Astrocytes derive energy …

Although glutamate is usually thought of as the major excitatory neurotransmitter in brain, it
is important to note that glutamate has many other fates in brain, including oxidation for …

Glutamine is an essential cerebral metabolite. Several critical brain processes are directly
linked to glutamine, including ammonia homeostasis, energy metabolism and …

The authors investigated concomitant lactate and glucose metabolism in primary neuronal
cultures using 13C-and 1H-NMR spectroscopy. Neurons were incubated in a medium …

Data acquired with functional magnetic resonance imaging (fMRI) and positron emission
tomography (PET) are often interpreted in terms of the underlying neuronal activity, despite …

Classical neuroenergetics states that glucose is the exclusive energy substrate of brain cells
and its full oxidation provides all the necessary energy to support brain function. Recent data …